Gene ML1985c (aceAa, aceAb)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) |
| Comments | ML1985c, len: 798 aa. Probable aceA, isocitrate lyase (EC 4.1.3.1). Previously sequenced as Mycobacterium leprae isocitrate lyase SW:ACEA_MYCLE (P46831) (606 aa), Fasta scores: E(): 0, 99.8% identity in 568 aa overlap. Similar to M. tuberculosis isocitrate lyase N-terminal and C-terminal modules aceAa Rv1915 TR:O07718 (EMBL:Z97193) (367 aa), Fasta scores: E(): 0, 87.1% identity in 295 aa overlap and aceAb Rv1916 TR:O07717 (EMBL:Z97193) (398 aa), Fasta scores: E(): 0, 87.9% identity in 397 aa overlap, and to many others e.g. Coprinus cinereus isocitrate lyase SW:ACEA_COPCI (O13439) (537 aa), Fasta scores: E(): 0, 38.1% identity in 586 aa overlap. Contains 2 Pfam matches to entry PF00463 ICL, Isocitrate lyase. Contains PS00161 Isocitrate lyase signature. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2369809 | 2372205 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1985c|aceA
LAGIPATVVQRCNSTNLDDRLHYSPLGDRAKEERNPMAIMDTNTEVHTLFTQEVAATQQYFDDPRFAGIIRLYTARQVVEQRGTIPTDYTVARDAATAFYARLRELFAAGKSVTTFGPYSPGQAVSLKRMGIEAIYLGGWATSAKGSITEDPGPDLASYPLSQVPDDAAVLVRALLAADRNQQYLRLHMTEQQRAATPAYDYRPFIIADADTGHGGDSHVRNLIRRFVEIGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATNLKIPSYKACFLALVRCFYELGVKELHGHLLYALGDGEYAAASAWLDRQGILAQVSGTVNAWQENGKQSIDDLFEQVEYRLLAAWEKDAGLMTYGEAVEEMLQFGESEGELIGMSPEEWRRFVGRASLYAAREKAKELGVDPGWDCELAKTPEGYYQIRGGIQYAIAKSLAAAPFADILWMETKTADLADARQFAEAIHAEFPEQMLAYNLSPSFNWDTTGMSDEEMKRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPKKLLEEWLALWSEHYQLGEKLRVQLRPRRAGSDVLELGIYGNGDEQLANVIVDPIKDRRGRSILQVRDQNTFAEKLRQKRLMTLIHFWLVHRFKADTVIYVTPTEDNLYQTSKMKSHGIFSEVYQEVGEIIVAEVNHPRLVELLTPDRVALRRLITKEG
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