Gene ML2028
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN CELL WALL MYCOLOYLATION. PROTEINS OF THE ANTIGEN 85 COMPLEX ARE RESPONSIBLE FOR THE HIGH AFFINITY OF MYCOBACTERIA TO FIBRONECTIN. POSSESSES A MYCOLYLTRANSFERASE ACTIVITY REQUIRED FOR THE BIOGENESIS OF TREHALOSE DIMYCOLATE (CORD FACTOR), A DOMINANT STRUCTURE NECESSARY FOR MAINTAINING CELL WALL INTEGRITY. |
| Product | SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR ALPHA-ANTIGEN) |
| Comments | ML2028, len: 327 aa. Probable fbpB, secreted antigen (85A), mycolyltransferase (EC 2.3.1.-). Similar to Mycobacterium kansasii antigen 85-B precursor SW:A85B_MYCKA (P21160) fasta scores: E(): 0, 85.8% in 324 aa, and to Mycobacterium avium antigen 85-B precursor SW:A85B_MYCAV (Q06947) fasta scores: E(): 0, 81.2% in 329 aa and P31952|A85B_MYCTU|Rv1886c Antigen 85-B precursor (85B) from M. tuberculosis (325 aa), fasta scores: E(): 1.6e-115, (83.025% identity in 324 aa overlap). Also similar to ML0097, ML2655 and ML0098 from M. leprae. Contains Pfam match to entry PF00756 Esterase, Putative esterase. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2418627 | 2419610 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2028|fbpB
MIDVSGKIRAWGRWLLVGAAATLPSLISLAGGAATASAFSRPGLPVEYLQVPSEAMGRSIKVQFQNGGNGSPAVYLLDGLRAQDDYNGWDINTSAFEWYYQSGLSVVMPVGGQSSFYSDWYSPACGKAGCTTYKWETFLTSELPKWLSANRSVKSTGSAVVGLSMAGSSALILAAYHPDQFIYAGSLSALMDSSQGIEPQLIGLAMGDAGGYKAADMWGPPNDPAWQRNDPILQAGKLVANNTHLWVYCGNGTPSELGGTNVPAEFLENFVHGSNLKFQDAYNGAGGHNAVFNLNADGTHSWEYWGAQLNAMKPDLQNTLMAVPRSG
Bibliography
No article yet recorded
