Gene ML2081c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | THOUGHT TO BE INVOLVED IN CARDIOLIPIN BIOSYNTHESIS; GENERATES CARDIOLIPIN FROM PHOSPHATIDYLGLYCEROL AND CDP-DIACYLGLYCEROL [CATALYTIC ACTIVITY : MAY BE: PHOSPHATIDYLGLYCEROL + PHOSPHATIDYLGLYCEROL -> CARDIOLIPIN + GLYCEROL, OR: CDP-DIACYLGLYCEROL + GLYCEROL 3-PHOSPHATE = CMP + 3-(3-PHOSPHATIDYL)-GLYCEROL 1-PHOSPHATE]. |
| Product | PROBABLECDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE PGSA2 (PGP SYNTHASE) (PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE) (3-PHOSPHATIDYL-1'-GLYCEROL-3'PHOSPHATE SYNTHASE) |
| Comments | ML2081c, len: 206 aa. Probable pgsA2, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase (EC 2.7.8.5). Similar to Mycobacterium tuberculosis putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl- transferase SW:PGSA_MYCTU (Q50611) fasta scores: E(): 0, 76.6% in 205 aa, and to Escherichia coli CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase SW:PGSA_ECOLI (P06978) fasta scores: E(): 4.5e-11, 30.5% in 177 aa. Also similar to ML0979 from M. leprae. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2472094 | 2472714 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2081c|pgsA2
MESVCPPNRVLTVPNLLSAVRLALIPAFVYVLLVMHADGWAVVILVFSGVSDWADGKIARLLDQYSRLGVLLDPAVDRLYMVTIPVVLALSGIVPWWFVVALLARDVLLTATLPLLWSRGLLSLPVTYIGKAATFSLMVGFPFVLLGTWDTLWSRVLGACGWAFLIWGTYAYLWAFVLYVVQMTMVVRWMPKIKHQAHRQFAGKAR
Bibliography
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