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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionTHOUGHT TO BE INVOLVED IN CARDIOLIPIN BIOSYNTHESIS; GENERATES CARDIOLIPIN FROM PHOSPHATIDYLGLYCEROL AND CDP-DIACYLGLYCEROL [CATALYTIC ACTIVITY : MAY BE: PHOSPHATIDYLGLYCEROL + PHOSPHATIDYLGLYCEROL -> CARDIOLIPIN + GLYCEROL, OR: CDP-DIACYLGLYCEROL + GLYCEROL 3-PHOSPHATE = CMP + 3-(3-PHOSPHATIDYL)-GLYCEROL 1-PHOSPHATE].
ProductPROBABLECDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE PGSA2 (PGP SYNTHASE) (PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE) (3-PHOSPHATIDYL-1'-GLYCEROL-3'PHOSPHATE SYNTHASE)
CommentsML2081c, len: 206 aa. Probable pgsA2, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase (EC 2.7.8.5). Similar to Mycobacterium tuberculosis putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl- transferase SW:PGSA_MYCTU (Q50611) fasta scores: E(): 0, 76.6% in 205 aa, and to Escherichia coli CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase SW:PGSA_ECOLI (P06978) fasta scores: E(): 4.5e-11, 30.5% in 177 aa. Also similar to ML0979 from M. leprae. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00379 CDP-alcohol phosphatidyltransferases signature.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS24720942472714-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML2081c|pgsA2
MESVCPPNRVLTVPNLLSAVRLALIPAFVYVLLVMHADGWAVVILVFSGVSDWADGKIARLLDQYSRLGVLLDPAVDRLYMVTIPVVLALSGIVPWWFVVALLARDVLLTATLPLLWSRGLLSLPVTYIGKAATFSLMVGFPFVLLGTWDTLWSRVLGACGWAFLIWGTYAYLWAFVLYVVQMTMVVRWMPKIKHQAHRQFAGKAR
      
Bibliography
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