Gene ML2123 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameprrA
Gene length702 bp
IdentifierML2123
Location 2524157 bp
Protein summary information
Molecular mass25109.7 Da
Isoelectric point4.74
Protein length234 amino acids
Structural information
PFAMPF00072, PF00486
Orthologs
M. tuberculosis H37RvRv0903c
M. lepromatosis Mx1-22AMLPM_2123
Cross-references
UniProtQ50136
Gene OntologyCytoplasm, Regulation of transcription, dna-dependent, GO:0006350, Phosphorelay response regulator activity, Phosphorelay signal transduction system, Dna binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductTWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA
CommentsML2123, len: 233 aa. Probable prrA, two-component response regulator. Similar to Mycobacterium tuberculosis probable transcriptional activator protein cy31.31c Rv0903c TR:Q10531 (EMBL:Z73101) fasta scores: E(): 0, 95.7% in 233 aa, and to Pseudomonas syringae transcriptional activator protein copr SW:COPR_PSESM (Q02540) fasta scores: E(): 2.5e-32, 43.6% in 225 aa. Contains Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain.
Functional categoryRegulatory proteins
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS25241572524858+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2123|prrA
MDTGVSSPRVLVVDDDSDVLASLERGLRLSGFEVSTAIDGAEALRNATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGATATSSSETIAVGPLEVDIPGRRARVNGVDVDLTKREFDLLAVLAEHKTTVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEANSGPRLLHTVRGVGFVLRMQ
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