Gene ML2162c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | POSSIBLE ACYL-CoA THIOLASE FADA |
| Comments | ML2162c, len: 403 aa. Possible fadA, acyl-CoA thiolase (EC 2.3.1.-). Similar to Mycobacterium tuberculosis putative acyl- CoA thiolase Rv0859 TR:O53871 (EMBL:AL022004) fasta scores: E(): 0, 94.5% in 403 aa, and to Escherichia coli acetyl-coa acetyltransferase TR:O53017 (EMBL:X97452) fasta scores: E(): 0, 44.1% in 422 aa, and to Acinetobacter calcoaceticus beta-ketoadipyl coa thiolase SW:PCAF_ACICA (Q43974) fasta scores: E(): 0, 40.9% in 425 aa. Also similar to ML1158 and ML2564 from M. leprae. Contains Pfam match to entry PF00108 thiolase, Thiolase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00098 Thiolases acyl-enzyme intermediate signature. Contains PS00099 Thiolases active site. Contains PS00737 Thiolases signature 2. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2571317 | 2572528 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2162c|fadA
MSEEAFIYEAIRTPRGKQKNGSLHEVKPVSLVVGLVEELRKRNPDLDENLISDVILGCVSPVGDQGGDIARATVLAAGLPVTAGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAMGLDPATNYDVMFVPQGIGADLIATIEGFSRDDVDVYALRSQEKAAAAWSGGYFAKSVVPVRDQNGLLILDHDEHMRPDTSKEGLAKLKPAFEGLAAMGGFDDVALQKYHWVEKINHVHTGGNSSGIVDGAALVMIGSEAVGKSQGLTPRARMVATATSGADPVIMLTGPTPATRKVLDRAGLTVDDIDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMILGTMVDELERCNARRALVTLCIGAGMGVATIIERV
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