Gene ML2219c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepurQ
Gene length675 bp
IdentifierML2219c
Location 2636012 bp
Protein summary information
Molecular mass23785.9 Da
Isoelectric point4.65
Protein length225 amino acids
Structural information
PFAMPF07685
Orthologs
M. tuberculosis H37RvRv0788
M. lepromatosis Mx1-22AMLPM_2219
Cross-references
UniProtO05756
Gene OntologyAtp binding, Cobalamin biosynthetic process, Cytoplasm, Glutamine metabolic process, Phosphoribosylformylglycinamidine synthase activity, 'de novo' imp biosynthetic process, Ligase activity, forming carbon-nitrogen bonds
Enzyme Classification6.3.5.3
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE I PURG (FGAM SYNTHASE I)
CommentsML2219c, len: 224 aa. Probable purQ, phosphoribosylformylglycinamidine synthase I (EC 6.3.5.3). Similar to Mycobacterium tuberculosis putative phosphoribosylformylglycinamidine synthase I Rv0788 OR MTCY369.32 TR:P71841 (EMBL:Z80226) fasta scores: E(): 0, 88.7% identity in 222 aa, and to Bacillus subtilis phosphoribosylformylglycinamidine synthase I PURQ SW:PURQ_BACSU (P12041) fasta scores: E(): 0, 47.2% identity in 214 aa. Contains PS00442 Glutamine amidotransferases class-I active site.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26360122636686-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2219c|purQ
VNARIGVITFPGTLDDVDAARAARHVGAEAVSLWHADADLKGVDAVVVPGGFSYGDYLRAGAIARLSPIMTEVVDAVQRGMPVLGICNGFQVLCEAGLLPGALIRNVGLHFICRDVWLRVISTSTAWTSRFEPETDLLVSLKSGEGRYVASENVLDELDGEGRVVFRYHDNINGSLRDIAGISSANGRVVGMMPHPEHAIEVLTGPSDDGLGLFYSALDSVLAS
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