Gene ML2235c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepurD
Gene length1269 bp
IdentifierML2235c
Location 2653344 bp
Protein summary information
Molecular mass43952.1 Da
Isoelectric point5.47
Protein length423 amino acids
Structural information
PFAMPF01071, PF02843, PF02844
Orthologs
M. tuberculosis H37RvRv0772
M. lepromatosis Mx1-22AMLPM_2235
Cross-references
UniProtQ50144
Gene OntologyMagnesium ion binding, Manganese ion binding, Phosphoribosylamine-glycine ligase activity, Purine nucleobase biosynthetic process, Purine nucleotide biosynthetic process, Atp binding
Enzyme Classification6.3.4.13
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE) (5'-PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE)
CommentsML2235c, len: 422 aa. Probable purD, phosphoribosylamine-glycine ligase(EC 6.3.4.13). Similar to Mycobacterium tuberculosis phosphoribosylamine--glycine ligase PurD OR Rv0772 OR MTCY369.17 SW:PUR2_MYCTU (P71827) fasta scores: E(): 0, 81.8% identity in 418 aa, and to Salmonella typhimurium phosphoribosylamine--glycine ligase PurD SW:PUR2_SALTY (P26977) fasta scores: E(): 0, 43.2% identity in 426 aa. Contains Pfam match to entry PF01071 GARS, Phosphoribosylglycinamide synthetase (GARS). Contains PS00184 Phosphoribosylglycinamide synthetase signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26533442654612-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2235c|purD
VRVLVIGSGAREHALLLALSRDPQVKGLVVAPGNAGTARLAEQYDVDISSGEDIVALARDVRADMVVIGPELPLVLGVADAVRAAGIVCFGPSKDAARIEGSKAFAKEVMAAAGVRTSRSEIVNSPARLDAALDRFGPPVGDLSWVVKDDRLAAGKGVVVTSDRDVARTHAAGLLEAGHPVLLESYLDGPEVSLFCVVDGRTVLPLLPAQDFKRVGEGDTGPNTGGMGAYAPLPWLPDEVCQQALTSIVEPVAAELVQRGSPFRGLLYVGLAVTASGPAVVEFNCRFGDPETQVVLALLDSPLGQLLYAAGTGSLADFGELHWRSGAAVAVVLAAENYPRRPRVGDIVFGSEIEGVLHAGTTRRDDGVIVSSGGRVLSVVATGDDLSAARSQAYRIIGSIRLLGSHFRKDIGFSAAKGRIHI
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