Gene ML2269 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namebpoC
Gene length798 bp
IdentifierML2269
Location 2692771 bp
Protein summary information
Molecular mass28702.7 Da
Isoelectric point6.13
Protein length266 amino acids
Structural information
PFAMPF00561
Orthologs
M. tuberculosis H37RvRv0554
M. lepromatosis Mx1-22AMLPM_2269
Cross-references
UniProtQ9CBB1
Gene OntologyHydrolase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE PEROXIDASE BPOC (NON-HAEM PEROXIDASE)
CommentsML2269, len: 265 aa. Possible bpoC, peroxidase (EC 1.11.1.-). Similar to Mycobacterium tuberculosis hypothetical protein Rv0554 or MTCY25D10.33 TR:O06420 (EMBL:Z95558) (262 aa) fasta scores: E(): 0, 83.5% identity in 261 aa. Shows weak similarity to various hydrolases e.g. Rhodococcus opacus 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase pcaL TR:O67982 (EMBL:AF003947) (400 aa) fasta scores: E(): 1.9e-11, 27.4% identity in 266 aa. Also similar to oxidoreductases which have an alpha/beta hydrolase fold e.g. Streptomyces aureofaciens non-haem bromoperoxidase bpoA2 SW:BPA2_STRAU (P29715) (277 aa) fasta scores: E(): 1.6e-13, 29.5% identity in 275 aa. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26927712693568+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2269|bpoC
VINLAYEDRGTGEPVVFIAGRGGAGRTWQPHQVPAFLAAGYRVITFDNRGIGATENTEGFTTQTMVADTAVLIESLGAVPARIVGVSMGSFIAQELMVARPELVRAAVLMATRGRLDRTRQFFHAAEAEFHDSGIQLPSGYNAKVRLLENLSRKTLNDDVAVADWIAMFNMWPIKSTPGLRCQTDVAPQNNRLPAYRSIAAPVLVIGFAEDVVTPPSLGREVADVLPNGRYLQIPDAGHLGFFERPEAVNAAALQFFAGVKGEWP
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