Gene ML2273 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemenH
Gene length717 bp
IdentifierML2273
Location 2697290 bp
Protein summary information
Molecular mass25719.3 Da
Isoelectric point9.42
Protein length239 amino acids
Structural information
PFAMPF01209
Orthologues
M. tuberculosisRv0558
Cross-references
UniProtQ9CBA8
Gene OntologyMethyltransferase activity, Menaquinone biosynthetic process
Enzyme Classification2.1.1.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE UBIQUINONE/MENAQUINONE BIOSYNTHESIS METHYLTRANSFERASE MENH (2-heptaprenyl-1,4-naphthoquinone methyltransferase)
CommentsML2273, len: 238 aa. Probable menH, ubiquinone/menaquinone biosynthesis methyltransferase (EC 2.1.1.-). Similar to Mycobacterium tuberculosis putative ubiquinone/menaquinone biosynthesis methyltransferase Rv0558 or MTCY25D10.37 TR:O06424 (EMBL:Z95558) (234 aa) fasta scores: E(): 0, 83.3% identity in 228 aa. Similar to many e.g. Streptomyces coelicolor putative ubiquinone/menaquinone methyltransferase SC10A7.27C TR:Q9XAP8 (EMBL:AL078618) (231 aa) fasta scores: E(): 0, 64.9% identity in 225 aa and to Escherichia coli ubiquinone/menaquinone biosynthesis methyltransferase UbiE ubiE SW:UBIE_ECOLI (P27851) (251 aa) fasta scores: E(): 2.7e-19, 42.8% identity in 229 aa. Contains Pfam match to entry PF01209 Ubie_methyltran, ubiE/COQ5 methyltransferase family.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26972902698006+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2273|menH
LPPGSVDVVSRAALDKDPRDVVAMFDDVAHRYDLTNTVLSLGQDRYWRRATRSALRIGPGQKVLDLAAGTAVSTAELSKSGAWCVAADFSVRMLATGGARKVPKVAADATQLPFSDGVFDAVTISFGLRNIADYQAALREMARVTRPGGQLVVCEFSTPTNALVANVYTEYLMRALPQVARLVSSNPDAYIYLAESIRAWPDQVTLACQLSRTGWASPRWRNLTGGIVALHAADKPVR
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