Gene ML2301c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | HAS BOTH AN APURINIC AND/OR APYRIMIDINIC ENDONUCLEASE ACTIVITY AND A DNA N-GLYCOSYLASE ACTIVITY. INCISES DAMAGED DNA AT CYTOSINES, THYMINES AND GUANINES. ACTS ON A DAMAGED STRAND (OXIDIZED PYRIMIDINES), 5' FROM THE DAMAGED SITE [CATALYTIC ACTIVITY: ENDONUCLEOLYTIC CLEAVAGE NEAR APURINIC OR APYRIMIDINIC SITES TO PRODUCTS WITH 5'-PHOSPHATE]. |
| Product | PROBABLE ENDONUCLEASE III NTH (DNA-(APURINIC OR APYRIMIDINIC SITE)LYASE) (AP LYASE) (AP ENDONUCLEASE CLASS I) (ENDODEOXYRIBONUCLEASE (APURINIC OR APYRIMIDINIC)) (DEOXYRIBONUCLEASE (APURINIC OR APYRIMIDINIC)) |
| Comments | ML2301c, len: 253 aa. Probable nth, endonuclease III. Similar to Mycobacterium tuberculosis endonuclease III ntH or Rv3674c or MTV025.022C SW:END3_MYCTU (O69642) (245 aa) fasta scores: E(): 0, 89.4% identity in 226 aa. Similar to many e.g. Micrococcus luteus ultraviolet N-glycosylase/ap lyase pdG SW:UVEN_MICLU (P46303) (279 aa) fasta scores: E(): 0, 57.7% identity in 246 aa and to Escherichia coli endonuclease III ntH SW:END3_ECOLI (P20625) (211 aa) fasta scores: E(): 7.6e-24, 36.6% identity in 205 aa. Contains Pfam match to entry PF00730 Endonuclease_3, Endonuclease III. Contains PS01155 Endonuclease III family signature. Contains PS00764 Endonuclease III iron-sulfur binding region signature. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2725730 | 2726491 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2301c|nth
MPLTPGVDVARRWSGETRLGLVRRARRMNRALAQAFPHVYCELDFTSPLELTVATILSAQSTDKRVNLTTPAVFARYRSALDYMQADRAELENFIRPTGFFRNKAASLIRLGQALVERFDGEVPSTMVDLFTLPGVGRKTANVILGNAFGIPGITVDTHFGRLVRRWRWTAEEDPVKVEHAVGELIERDQWTLLSHRVIFHGRRVCHARKPACGVCVLAKDCPSFGLGPTEPLLAAPLVQGPEAGHLLALAGL
Bibliography
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