Go to browser
virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionINVOLVED IN LEUCINE BIOSYNTHESIS (AT THE FIRST STEP). CATALYZES CONDENSATION OF ACETYL-CoA AND 2-OXOISOVALERATE TO FORM 2-ISOPROPYLMALATE SYNTHASE [CATALYTIC ACTIVITY: 3-CARBOXY-3-HYDROXY-4-METHYLPENTANOATE + CoA = ACETYL-COA + 3-METHYL-2-OXOBUTANOATE + H(2)O].
Product2-ISOPROPYLMALATE SYNTHASE LEUA (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE)
CommentsML2324, len: 607 aa. leu, 2-isopropylmalate synthase (EC 4.1.3.12). Similar to Mycobacterium tuberculosis 2-isopropylmalate synthase leuA or Rv3710 SW:LEU1_MYCTU (P96420; O69677) (644 aa) fasta scores: E(): 0, 80.7% identity in 642 aa, and to Corynebacterium glutamicum 2-isopropylmalate synthase leuA SW:LEU1_CORGL (P42455) (616 aa) fasta scores: E(): 0, 66.8% identity in 602 aa. Contains Pfam match to entry PF00682 HMGL-like, HMGL-like. Contains PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. Contains PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS27546472756470+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML2324|leuA
VASFSESLSQDPADAYKSAPSITKPMGPPSPGQPQWNPQRATSMPVFRYRPFAKEVEPIRLVDRTWPDRVIDCAPLWCAVDLRDGNQALIDPMSPICKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIITDGTIPDDVTIQVLTQCRPELIERTFEACENASRVIVHFYNSTSILQRRVVFRADQATVKAIATDGARKCVEEAFKYPGTHWRFEYSPESYTGTELEYAKQVCDAVGEVIQPTPDNPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGYHAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNKLRVHERHPYGGDLVYTAFSGSHQDAINKGLDQMKIDADAADSDVDDILWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKADHGLELPRRLQIEFSRAIQKISEGEGGEITPTEMWDVFFEEYLSPVQPLERIKQRVNAAEEDGGSTSIAATVKINGEETEISGVGNGPLAAFIDALGHVGLQVAVLDYSEHAMNAGDDAQAAAYVEASVHGHTAWGVGIAPSITTASLRAVVSAVNRAMPR
      
Bibliography
No article yet recorded