Gene ML2324 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameleuA
Gene length1824 bp
IdentifierML2324
Location 2754647 bp
Protein summary information
Molecular mass66866.0 Da
Isoelectric point4.67
Protein length608 amino acids
Structural information
PFAMPF00682, PF08502
Orthologs
M. tuberculosis H37RvRv3710
M. lepromatosis Mx1-22AMLPM_2324
Cross-references
UniProtQ9CB76
Gene OntologyLeucine biosynthetic process, 2-isopropylmalate synthase activity
Enzyme Classification2.3.3.13
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionINVOLVED IN LEUCINE BIOSYNTHESIS (AT THE FIRST STEP). CATALYZES CONDENSATION OF ACETYL-CoA AND 2-OXOISOVALERATE TO FORM 2-ISOPROPYLMALATE SYNTHASE [CATALYTIC ACTIVITY: 3-CARBOXY-3-HYDROXY-4-METHYLPENTANOATE + CoA = ACETYL-COA + 3-METHYL-2-OXOBUTANOATE + H(2)O].
Product2-ISOPROPYLMALATE SYNTHASE LEUA (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE)
CommentsML2324, len: 607 aa. leu, 2-isopropylmalate synthase (EC 4.1.3.12). Similar to Mycobacterium tuberculosis 2-isopropylmalate synthase leuA or Rv3710 SW:LEU1_MYCTU (P96420; O69677) (644 aa) fasta scores: E(): 0, 80.7% identity in 642 aa, and to Corynebacterium glutamicum 2-isopropylmalate synthase leuA SW:LEU1_CORGL (P42455) (616 aa) fasta scores: E(): 0, 66.8% identity in 602 aa. Contains Pfam match to entry PF00682 HMGL-like, HMGL-like. Contains PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. Contains PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS27546472756470+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2324|leuA
VASFSESLSQDPADAYKSAPSITKPMGPPSPGQPQWNPQRATSMPVFRYRPFAKEVEPIRLVDRTWPDRVIDCAPLWCAVDLRDGNQALIDPMSPICKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIITDGTIPDDVTIQVLTQCRPELIERTFEACENASRVIVHFYNSTSILQRRVVFRADQATVKAIATDGARKCVEEAFKYPGTHWRFEYSPESYTGTELEYAKQVCDAVGEVIQPTPDNPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGYHAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNKLRVHERHPYGGDLVYTAFSGSHQDAINKGLDQMKIDADAADSDVDDILWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKADHGLELPRRLQIEFSRAIQKISEGEGGEITPTEMWDVFFEEYLSPVQPLERIKQRVNAAEEDGGSTSIAATVKINGEETEISGVGNGPLAAFIDALGHVGLQVAVLDYSEHAMNAGDDAQAAAYVEASVHGHTAWGVGIAPSITTASLRAVVSAVNRAMPR
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