Gene ML2335c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | DNA POLYMERASE III IS A COMPLEX, MULTICHAIN ENZYME RESPONSIBLE FOR MOST OF THE REPLICATIVE SYNTHESIS IN BACTERIA. THIS DNA POLYMERASE ALSO EXHIBITS 3' TO 5' EXONUCLEASE ACTIVITY [CATALYTIC ACTIVITY: N DEOXYNUCLEOSIDE TRIPHOSPHATE = N PYROPHOSPHATE + DNA(N)]. |
| Product | DNA POLYMERASE III (SUBUNIT GAMMA/TAU) DNAZ/X |
| Comments | ML2335c, len: 611 aa. dnaZX, DNA polymerase III, subunit gamma/tau (EC 2.7.7.7). Highly similar to many DNA polymerase III subunit gamma/tau including: Mycobacterium tuberculosis DnaZX Rv3721c SW:DP3X_MYCTU (O69688) (578 aa) fasta scores: E(): 0, 78.7% identity in 602 aa and to Escherichia coli SW:DP3X_ECOLI (P06710; Q47721) (643 aa) fasta scores: E(): 0, 34.2% identity in 521 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2765714 | 2767549 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2335c|dnaZX
VTLYRKYRPAAFAEVVGQEHVTEPLSIALEAGRINHAYLFSGPRGCGKTSSARILARSLNCAQGTTATPCGVCESCLSLAPNAPGHIDVVELDAASHGGVDDTRELRDRAFYAPAQSRYRVFIVDEAHMVTTAGFNALLKIVEEPPDHLIFIFATTEPEKVLPTIRSRTHHYPFRLLSPRTMRALVGRICAQEGVVVDDAVYPLVIRAGGGSPRDTLSVLDQLVAGAEGEHVTYQRALKLLGATDVGLIDDAVDALGAHDAAALFGAVESVIDAGHDPRRFATDLLERFRDLIVLQAVPDAAARGVVDASEDVLDRMREQAVRIGPATLTRYAEVVHSGLGEMRGATAPRLLLEVVCARLLLPSATDAESALLQRVERIETRLNMSIPAARAAYPLQSAPAEKAAQPSLPHQPFLASPDSQPAPDAQSSKLATPQAAAEPTPGMGAPNAAAVRTMWSTVREKVRQRSRTTEVMLAGATVRAVEDNTLILTHGSAPLAKRLSEQHNVDVIAEALKDALGVNWRVRCEAGVPVPAVGALPACEGMVALPTQEKVPVLDVASAQQYEDEGMLAEPGRRDLSAPRPDLEEVALELLQNELGARRIDKWLTDAVED
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