Gene ML2351c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | PROBABLY INVOLVED IN ACTIVE TRANSPORT OF ANTIBIOTIC AND PHTHIOCEROL DIMYCOCEROSATE (DIM) ACROSS THE MEMBRANE (EXPORT). DRRA|Rv2934|MTCY19H9.04, DRRB AND DRRC|Rv2938|MTCY19H9.06 MAY ACT JOINTLY TO CONFER DAUNORUBICIN AND DOXORUBICIN RESISTANCE BY AN EXPORT MECHANISM. PROBABLY RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE AND LOCALIZATION OF DIM INTO THE CELL WALL. |
| Product | PROBABLE DAUNORUBICIN-DIM-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DRRB |
| Comments | ML2351c, len: 288 aa. Probable drrB, daunorubicin-DIM-transport integral membrane protein ABC transporter, probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport. Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis Rv2937 TR:P96206 (EMBL:Z83857) (289 aa) fasta scores: E(): 0, 64.0% identity in 289 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 4.2e-06, 22.7% identity in 229 aa. Also similar to the adjoining CDS ML2350. Contains possible membrane spanning hydrophobic domains. |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2793066 | 2793932 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2351c|drrB
MSMPALAPIPASRWPSTIMAKPRRSTLRQWWALTTRYYTDIKLFVFEKTIQIGAPVVFTVGLYLPFAIPWNHFVGGPSSGIASNLGQYVTPLIVLQSIAFAAIGSAFRAATDSLRGISRRFRTMPIAPVTPVLARVTDAVQRCCWGMGVALICGHVIGFQFHRGPLYIVGFCALVLAIGAALSFAADLLGTAIRNPDAMLPLLTLPILIFGLLSVGLMPVKLFPRWIHPFVLNQPVSQFVVALRALAGETTKTVIPVAWSVMVPTLAWLFGFLVVLVPICLVILFRRT
Bibliography
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