Gene ML2352c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | PROBABLY INVOLVED IN ACTIVE TRANSPORT OF ANTIBIOTIC AND PHTHIOCEROL DIMYCOCEROSATE (DIM) ACROSS THE MEMBRANE (EXPORT). DRRA, DRRB|Rv2936|MTCY19H9.05 AND DRRC|Rv2938|MTCY19H9.06 MAY ACT JOINTLY TO CONFER DAUNORUBICIN AND DOXORUBICIN RESISTANCE BY AN EXPORT MECHANISM. RESPONSIBLE FOR ENERGY COUPLING TO THE TRANSPORT SYSTEM. |
| Product | PROBABLE DAUNORUBICIN-DIM-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER DRRA |
| Comments | ML2352c, len: 331 aa. Probable drrA, daunorubicin-DIM-transport resistance ATP-binding protein ABC transporter, probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport. Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis Rv2936 TR:P96205 (EMBL:Z83857) (331 aa) fasta scores: E(): 0, 85.2% identity in 331 aa and Streptomyces peucetius daunorubicin resistance ATP-binding protein DrrA SW:DRRA_STRPE (P32010) (330 aa) fasta scores: E(): 0, 46.0% identity in 322 aa. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2793929 | 2794924 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2352c|drrA
MRNNDKAVMVRGVRKTYGKGKIIALDDVSFDVDRGEVIGLLGPNGAGKTTMVDILSTLTRPDRGLATVAGYDVVSEPAGVRRSIMVTGQQVAVDDQLSGEQNLILFGRLYGLSKSVARVRTQELLEQFDLLHAGKRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFKQIGIATLLTTQYLEEADELSDRIILIDHGTVIAEGTASELKHRVGETFCEIVPRDLKDLGTVVAALGSLLPERSRAMLTPTSDRITMPAPDGTQTLIEAARRIDEVSVELADIALRRPSLDDVFLSMTTDPSESLSHLAAGAMR
Bibliography
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