Gene ML2393
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | NECESSARY FOR EFFICIENT RNA POLYMERASE TRANSCRIPTION ELONGATION PAST TEMPLATE-ENCODED ARRESTING SITES. THE ARRESTING SITES IN DNA HAVE THE PROPERTY OF TRAPPING A CERTAIN FRACTION OF ELONGATING RNA POLYMERASES THAT PASS THROUGH, RESULTING IN LOCKED TERNARY COMPLEXES. CLEAVAGE OF THE NASCENT TRANCRIPT BY CLEAVAGE FACTORS SUCH AS GREA OR GREB ALLOWS THE RESUMPTION OF ELONGATION FROM THE NEW 3'TERMINUS. GREA RELEASES SEQUENCES OF 2 TO 3 NUCLEOTIDES |
| Product | PROBABLE TRANSCRIPTION ELONGATION FACTOR GREA (Transcript cleavage factor greA) |
| Comments | ML2393, len: 164 aa. Probable greA, transcription elongation factor G. Similar to Mycobacterium tuberculosis transcription elongation factor Rv1080c SW:GREA_MYCTU (O53428) (164 aa) fasta scores: E(): 0, 94.5% identity in 164 aa, and to Escherichia coli transcription elongation factor GreA SW:GREA_ECOLI (P21346; P78111) (158 aa) fasta scores: E(): 1e-08, 34.6% identity in 159 aa. Contains Pfam match to entry PF01272 GreA_GreB, Prokaryotic transcription elongation factor, GreA/GreB. Contains PS00829 Prokaryotic transcription elongation factors signature 1. Contains PS00830 Prokaryotic transcription elongation factors signature 2. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2863244 | 2863738 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2393|greA
MTDTQVTWLTQESHDRLKAELDQLIANRPVIAAEINDRREEGDLRENGGYHAAREEQGQQEARIRQLQDLLNIAKVGEAPKQSGVALPGSVVKVYYNDDKSDTETFLIATRQEGVNEGKLEVYSPNSPLGGALIDAKVGETRSYTVPNGNTVQVTLISAEPYHS
Bibliography
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