Gene ML2421c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN PORPHYRIN BIOSYNTHESIS BY THE C5 PATHWAY (AT THE FOURTH STEP). TETRAPOLYMERIZATION OF THE MONOPYRROLE PBG INTO THE HYDROXYMETHYLBILANE PREUROPORPHYRINOGEN IN SEVERAL DISCRETE STEPS [CATALYTIC ACTIVITY: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3]. |
| Product | PROBABLE PORPHOBILINOGEN DEAMINASE HEMC (PBG) (HYDROXYMETHYLBILANE SYNTHASE) (HMBS) (PRE-UROPORPHYRINOGEN SYNTHASE) |
| Comments | ML2421c, len: 318 aa. Probable hemC, porphobilinogen deaminase (EC 4.3.1.8). Similar to Mycobacterium tuberculosis porphobilinogen deaminase Rv0510 SW:HEM3_MYCTU (Q11173) (309 aa) fasta scores: E(): 0, 87.0% identity in 308 aa, and to Escherichia coli porphobilinogen deaminase HemC SW:HEM3_ECOLI (P06983; P78125) (313 aa) fasta scores: E(): 8.4e-30, 42.9% identity in 312 aa. Contains Pfam match to entry PF01379 Porphobil_deam, Porphobilinogen deaminase. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2896541 | 2897497 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2421c|hemC
LAHVIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDPVQMVPAPAQGAIAVECRAGDSRLVAVLAALDDADTRAAVTAERVLLAELEAGCSAPVGAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGARELMWGARSDRARGS
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