Gene ML2503c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namermlA
Gene length867 bp
IdentifierML2503c
Location 2984308 bp
Protein summary information
Molecular mass31325.7 Da
Isoelectric point4.96
Protein length289 amino acids
Structural information
PFAMPF00483
Orthologs
M. tuberculosis H37RvRv0334
M. lepromatosis Mx1-22AMLPM_2503
Cross-references
UniProtQ9CB18
Gene OntologyGlucose-1-phosphate thymidylyltransferase activity, Extracellular polysaccharide biosynthetic process
Enzyme Classification2.7.7.24
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductALPHA-D-GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE RMLA (DTDP-GLUCOSE SYNTHASE) (DTDP-GLUCOSE PYROPHOSPHORYLASE)
CommentsML2503c, len: 288 aa. Probable rmlA, glucose-1-phosphate thymidyltransferase (EC 2.7.7.24). Similar to Mycobacterium tuberculosis glucose-1-phosphate thymidylyltransferase Rv0334 TR:P72017 (EMBL:U55242) fasta scores: E(): 0, 86.9% id in 282 aa, and to Escherichia coli glucose-1-phosphate thymidylyltransferase RfbA SW:RBA2_ECOLI (P55253) fasta scores: E(): 0, 61.1% identity in 283 aa. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS29843082985174-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2503c|rmlA
MRGIILAGGSGTRLYPITLGISKQLLPVYDKPMIYYPLSTLMMAGIRDILVITTAHDAPGFKRLLGDGTQFGVNISYATQDHPDGLAQAFVIGANHIGADTVALVLGDNIFYGPGLGTSLRRFQYVSGGAIFAYCVANPSSYGIVELGIDGIALSLEEKPATPKSQYAVPGLYFYDNDVVEIARGLTKSARGEYEITEVNQIYLNQGRLTVEVLARGTAWLDTGTFDSLLDASDFVRTLERRQGLKVSVPEEVSWRMGWIDDEQLALRAHSLAKSGYGCYLSELLERG
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