Gene ML2608c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameilvD
Gene length1695 bp
IdentifierML2608c
Location 3113033 bp
Protein summary information
Molecular mass58782.4 Da
Isoelectric point5.24
Protein length565 amino acids
Structural information
PFAMPF00920
Orthologs
M. tuberculosis H37RvRv0189c
M. lepromatosis Mx1-22AMLPM_2608
Cross-references
UniProtO06069
Gene OntologyDihydroxy-acid dehydratase activity, Iron ion binding, Isoleucine biosynthetic process, Valine biosynthetic process, 4 iron, 4 sulfur cluster binding
Enzyme Classification4.2.1.9
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE DIHYDROXY-ACID DEHYDRATASE ILVD (DAD)
CommentsML2608c, len: 564 aa. Probable ilvD, dihydroxy-acid dehydratase (EC 4.2.1.9). Similar to many Prokaryotic and Eukaryotic dihydroxy-acid dehydratases involved in valine and isoleucine biosynthesis e.g. Mycobacterium tuberculosis Rv0189c SW:ILVD_MYCTU (O07433) fasta scores: E(): 0, 90.0% identity in 560 aa, Saccharomyces cerevisiae dihydroxy-acid dehydratase, mitochondrial precursor ILV3 OR YJR016C OR J1450 SW:ILV3_YEAST (P39522) fasta scores: E(): 0, 48.5% identity in 555 aa. Contains Pfam match to entry PF00920 ILVD_EDD, Dehydratase family. Contains PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS31130333114727-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2608c|ilvD
MMPPDIKPRSRDVTDGLEKAAARGMLRAVGMNDDDFAKAQIGVASSWNEITPCNLSLDRLAKAVKEGVFSAGGYPLEFGTISVSDGISMGHQGMHFSLVSREVIADSVETVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLASVFLYAGSILPGRTKLSDGTEHEVTLIDAFEAVGACSRGLMPRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLPGSAAPPATDRRRDGFARRSGQAVIELLRRGITARDILTKEAFENAIAVVMAFGGSTNAILHLLAIAHEADVTLSLEDFSRIGFKVPHIADVKPFGRHVMFDVDHIGGVPVVMKALLDAGLLHGDCLTVTGQTMAENLASIAPPDPDGQVIRTLHNPIHPTGGITILRGSLAPDGAVVKTAGLDSDVFEGTARVFDGERAALDALKDGTIAKGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRFSGGTTGFCVGHIAPEAVEAGPIAFLRDGDRVLLDVVGCSLDVLVDPVEFSSRKKDFIPPAPRYTTGVLAKYVKLVSSATVGAVCG
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