Gene ML2647
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | HAS AN IMPORTANT FUNCTION AS A REPAIR ENZYME FOR PROTEINS THAT HAVE BEEN INACTIVATED BY OXIDATION. CATALYZES THE REVERSIBLE OXIDATION-REDUCTION OF METHIONINE SULFOXIDE IN PROTEINS TO METHIONINE [CATALYTIC ACTIVITY: Protein L-methionine + oxidized thioredoxin = protein L-methionine S-oxide + reduced thioredoxin]. |
| Product | PROBABLE PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA (PROTEIN-METHIONINE-S-OXIDE REDUCTASE) (PEPTIDE MET(O) REDUCTASE) |
| Comments | ML2647, len: 177 aa. Probable msrA, peptide methionine sulfoxide reductase (EC 1.8.4.6). Similar to regions of several methionine sulfoxide reductases including: Pseudomonas fluorescens putative methionine sulfoxide reductase TR:O69761 (EMBL:L49465) fasta scores: E(): 0, 70.0% in 160 aa, and to Mycobacterium tuberculosis hypothetical 20.5 kda protein Rv0137c TR:P96814 (EMBL:Z92770) fasta scores: E(): 0, 80.0% in 170 aa, and to Escherichia coli peptide methionine sulfoxide reductase SW:PMSR_ECOLI (P27110) fasta scores: E(): 3e-25, 48.4% in 155 aa. Contains Pfam match to entry PF01625 PMSR, Peptide methionine sulfoxide reductase. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3166874 | 3167407 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2647|msrA
MARTNTRKAILAGGCFWGIQNLFRRQPGVISTRVGYTGGGTPNATYRNHGMHAEAVEIIYDPAITDYRTLLEFFFQIHDPTTRNRQGNDQGTSYRSAIFYLDDEQKKVALDTIAAVEASSLWPGKVVTEVSLAEDFWEAEPEHQDYLQHYPNGYTCHFVRPNWKLPRRAPADAKADS
Bibliography
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