Gene ML2712c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | RNaseP CATALYZES THE REMOVAL OF THE 5'-LEADER SEQUENCE FROM PRE-tRNA TO PRODUCE THE MATURE 5'TERMINUS. IT CAN ALSO CLEAVE OTHER RNA SUBSTRATES SUCH AS 4.5S RNA. THE PROTEIN COMPONENT PLAYS AN AUXILIARY BUT ESSENTIAL ROLE IN VIVO BY BINDING TO THE 5'-LEADER SEQUENCE AND BROADENING THE SUBSTRATE SPECIFICITY OF THE RIBOZYME [CATALYTIC ACTIVITY: ENDONUCLEOLYTIC CLEAVAGE OF RNA, REMOVING 5'-EXTRA-NUCLEOTIDE FROM tRNA PRECURSOR]. |
| Product | RIBONUCLEASE P PROTEIN COMPONENT RNPA (RNaseP PROTEIN) (RNase P PROTEIN) (PROTEIN C5) |
| Comments | ML2712c, len: 120 aa. rnpA, ribonuclease P protein component (EC 3.1.26.5). Similar to Mycobacterium tuberculosis ribonuclease P protein component Rv3923c SW:RNPA_MYCTU (Q50789; O53601) fasta scores: E(): 2.9e-26, 63.0% in 119 aa, and to Streptomyces bikiniensis ribonuclease P protein component SW:RNPA_STRBI (P25817) fasta scores: E(): 1.1e-08, 34.8% in 115 aa. Contains Pfam match to entry PF00825 Ribonuclease_P, Ribonuclease P. Contains PS00648 Bacterial ribonuclease P protein component signature. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3267135 | 3267497 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML2712c|rnpA
VLSACNRMRRSSEFDATVKFGLRAVQSDVIIHVWRGCNRDETKAPHVGLIIAKTVGSAVERHRVARRLRHVARTMLGELGGADQVVIRALPSSRNVSSAWLAQQLRNGLRCALDLAETDW
Bibliography
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