Gene MMAR_0373 in Mycobacterium marinum M
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameptpB
Gene length831 bp
IdentifierMMAR_0373
Location 438612 bp
Protein summary information
Molecular mass30164.8 Da
Isoelectric point5.0
Protein length277 amino acids
Orthologs
M. tuberculosis H37RvRv0153c
Cross-references
UniProtB2HLU1
Gene OntologyDephosphorylation, Phosphatase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
Functioninvolved in signal transduction (via dephosphorylation). can dephosphorylated in vitro the phosphotyrosine residue of myelin basic protein (MBP) at ph 7.0. could be involved in virulence by interfering with phosphotyrosine-mediated signals in macrophages [catalytic activity: protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate].
Productphosphotyrosine protein phosphatase PtpB
Comments-
Functional categoryRegulatory proteins
Coordinates
TypeStartEndOrientation
CDS438612439442-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_0373|ptpB
MAETGPELPGAWNFRDVADSTAALRPGRLFRSSELSGLDDQGRAALRRFKITDVADLRSSREVARRGPGQVPAGVDVHLLPFPDLADDQAGTDDNAPHETAFKRLLTDGDAGESSEAIDQVAARYMADEYRQFPMRTGAQRAVHRVFTLLAAGRPVLTHCFAGKDRTGFVVATVLEAVGVDREVILADYLRSNDAVPQLRDRISEMIRERTDVELTPEVVTFTKARLSDGVLGVRPEYLAAAWQTIDETFGSLDGYLADSGITEADRHQLRSALLG
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