Gene MMAR_1770 in Mycobacterium marinum M
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namedrrB
Gene length870 bp
IdentifierMMAR_1770
Location 2142161 bp
Protein summary information
Molecular mass30970.9 Da
Isoelectric point10.25
Protein length290 amino acids
Structural information
PFAMB2HIM5
Orthologs
M. tuberculosis H37RvRv2937
Cross-references
UniProtB2HIM5
Gene OntologyMembrane
Precomputed results
BLASTReport
General annotation
TypeCDS
Functionprobably involved in active transport of phthiocerol dimycocerosate (dim) across the membrane (export). DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. probably responsible for the translocation of the substrate across the membrane and localization of dim into the cell wall.
Productdaunorubicin-DIM-transport integral membrane protein ABC transporter DrrB
Comments-
Functional categoryCell wall and cell processes
Coordinates
TypeStartEndOrientation
CDS21421612143030-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_1770|drrB
VSISAVDPTPVPTFKGAGPSAAKPRLSTLQQWWVLVGRFTKPRLRDPELITMVGAPVVFTVGFYIPFAIPWNHYVGGGASGVASSLGQYIAPLIVLQSISFAAISSAFRAATDSLQGINRRFRYMPIAPLTPVVARVTAAIYRCCVGLTVALICGYAIGFHFNRGPLYIVGYCLLAIAIGAVLSFGADLLGTGTKNPDAMLPLLSLPILIFGLLSVGLMPLKLFPHWIHPFVRNQPITQFVVALRALAGDTTKAAIPVTWTVMTPTLAWLAGFALFLVPVSIIVLSRRP
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