Gene MMAR_2110 in Mycobacterium marinum M
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameruvA
Gene length594 bp
IdentifierMMAR_2110
Location 2540771 bp
Protein summary information
Molecular mass20272.2 Da
Isoelectric point5.93
Protein length198 amino acids
Structural information
PFAMB2HN62
Orthologues
M. tuberculosisRv2593c
Cross-references
UniProtB2HN62
Gene OntologyAtp binding, Dna binding, Dna recombination, Dna repair, Holliday junction helicase complex, Sos response, Four-way junction helicase activity
Enzyme Classification3.6.1.-
Precomputed results
BLASTReport
General annotation
TypeCDS
Functionforms a complex with RuvB. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. the RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reanneling.
ProductHolliday junction DNA helicase RuvA
Comments-
Functional categoryInformation pathways
Coordinates
TypeStartEndOrientation
CDS25407712541364+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_2110|ruvA
MISSLRGEVLEVALDHVVIEAAGVGYRVNATPSTLATLRQGTDARLITAMIVREDSMTLYGFVDGETRDLFLTLLSVSGVGPRLAMATLSVHDANGLRQALADGDVTALTRVPGIGKRGAERMVVELRDKVGPAGSAATAPAVNGHTVRAPVVEALVGLGFAAKQAEEATDKVLAGDGEATTSSALRAALSLLGKAR
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