Gene MMAR_3657 in Mycobacterium marinum M
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameplcB_4
Gene length1563 bp
IdentifierMMAR_3657
Location 4503965 bp
Protein summary information
Molecular mass56496.3 Da
Isoelectric point6.35
Protein length521 amino acids
Structural information
PFAMB2HL97
Orthologs
M. tuberculosis H37RvRv2351c
Cross-references
UniProtB2HL97
Gene OntologyHydrolase activity, acting on ester bonds
Precomputed results
BLASTReport
General annotation
TypeCDS
Functionhydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate].
Productmembrane-associated phospholipase C 2 PlcB_4
Comments-
Functional categoryVirulence, detoxification, adaptation
Coordinates
TypeStartEndOrientation
CDS45039654505527-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_3657|plcB_4
VSGNPFRGMSRREFIAKMTGAGAAALLMDYAGPVIEKAYGAGPCSGQLTDIEHIVLLMQENRSFDHYFGTLSSIRGFSDPSPAFQQKGWNPRTQALDPAGTTIPFRLDTTRGPFLDGECVNDPEHQWTAMHLSWNGGANDNWLPAQANTRTGPYVPMTMGYYTRQDIPIHHLLADTFTICDGYHCSLLTGTLPNRLYWMSAWNDPAGTNGGPQLVEPGFLPLHQYSWRIMPENLEDAGVSWKVYQNKDAGRFINTPISNNGLVQAFKQSGDPRSNLARYGIAPGYPVDFAADVKANRLPKVSWLVPNFLQSEHPALPVALGAVAMVTALRILLSNPAVWEKTALIISYDENGGFFDHVTPPTAPPGTPGEWVTVPDINSVPGSGGIRGPLGLGFRVPCIVVSPFSRGGLMVHDIFDHTSQLKLISKRFDVPVPNLTAWRDGVVGDMTSTFNFATPPNPSRPNLSHPLLAAVPKLPQCIPNVVLGTSDGTFPAIPYRVPYPQSMPGQESTPVRGVPSGLCV
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