Gene Mb0001 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namednaA
Gene length1524 bp
IdentifierMb0001
Location 1 bp
Protein summary information
Molecular mass56599.8 Da
Isoelectric point5.4045
Protein length507 amino acids
Orthologues
M. tuberculosisRv0001
Cross-references
UniProtP49991
UniProtKB/TrEMBLX2BDR0, P49991
General annotation
TypeCDS
FunctionUnknown
ProductCHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA
CommentsMb0001, dnaA, len: 507 aa. Equivalent to Rv0001,len: 507 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 507 aa overlap). dnaA, chromosomal replication initiator protein (see citations below),equivalent to other Mycobacterial CHROMOSOMAL REPLICATION INITIATOR PROTEINS e.g. P46388|DNAA_MYCLE from Mycobacterium leprae (502 aa); Q9L7L7|DNAA_MYCPA from Mycobacterium paratuberculosis (509 aa); P49990|DNAA_MYCAV from Mycobacterium avium (508 aa); P49992|DNAA_MYCSM from Mycobacterium smegmatis (504 aa); etc. Also highly similar to others except in N-terminus e.g. Q9ZH75|DNAA_STRCH CHROMOSOMAL REPLICATION INITIATOR PROTEIN from Streptomyces chrysomallus (624 aa); Q9ZH76|DNAA_STRRE from Streptomyces reticuli (643 aa); DNAA_ECOLI|P03004|B3702 chromosomal replication initiator protein from Escherichia coli strain K12 (467 aa), FASTA scores: opt: 986, E(): 0,(43.2% identity in 389 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS01008 DnaA protein signature. BELONGS TO THE DNAA FAMILY. Note that the first base of this gene has been taken as base 1 of the Mycobacterium bovis genomic sequence.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS11524+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0001|dnaA
MTDDPGSGFTTVWNAVVSELNGDPKVDDGPSSDANLSAPLTPQQRAWLNLVQPLTIVEGFALLSVPSSFVQNEIERHLRAPITDALSRRLGHQIQLGVRIAPPATDEADDTTVPPSENPATTSPDTTTDNDEIDDSAAARGDNQHSWPSYFTERPRNTDSATAGVTSLNRRYTFDTFVIGASNRFAHAAALAIAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFIEGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPPELETRIAILRKKAQMERLAIPDDVLELIASSIERNIRELEGALIRVTAFASLNKTPIDKALAEIVLRDLIADANTMQISAATIMAATAEYFDTTVEELRGPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAQRKILSEMAERREVFDHVKELTTRIRQRSKR
Bibliography
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