Gene Mb0006 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namegyrA
Gene length2517 bp
IdentifierMb0006
Location 7302 bp
Protein summary information
Molecular mass92301.4 Da
Isoelectric point5.3677
Protein length838 amino acids
Orthologs
M. tuberculosis H37RvRv0006
M. tuberculosis MTBC0mtbc0_000006
Cross-references
UniProtA0A1R3XU07
InterProIPR002205, IPR005743, IPR006691, IPR013758, IPR013760, IPR024946
UniProtKB/TrEMBLQ7U311
General annotation
TypeCDS
FunctionUnknown
ProductDNA GYRASE (SUBUNIT A) GYRA (DNA TOPOISOMERASE (ATP-HYDROLYSING)) (DNA TOPOISOMERASE II) (TYPE II DNA TOPOISOMERASE)
CommentsMb0006, gyrA, len: 838 aa. Equivalent to Rv0006,len: 838 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 838 aa overlap). gyrA, DNA gyrase subunit A (EC 5.99.1.3) (see citations below), equivalent,except in N-terminus, to other Mycobacterial DNA GYRASES SUBUNIT A e.g. Q57532|GYRA_MYCLE|T10006 from Mycobacterium leprae (1273 aa); P48354|GYRA_MYCSM from Mycobacterium smegmatis (842 aa); etc. Also highly similar to others e.g. P35885|GYRA_STRCO DNA GYRASE SUBUNIT A from Streptomyces coelicolor (864 aa); NP_346654.1|NC_003030 from Clostridium acetobutylicum (830 aa); NP_387888.1|NC_000964 from Bacillus subtilis (821 aa); etc. Contains PS00018 EF-hand calcium-binding domain.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS73029818+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0006|gyrA
MTDTTLPPDDSLDRIEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGRVYRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKSKLTAFDSNRSGGIVAVNLRDNDELVGAVLCSADDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVRKAGRQTKGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN
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