Gene Mb0014c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepknB
Gene length1881 bp
IdentifierMb0014c
Location 15589 bp
Protein summary information
Molecular mass66509.8 Da
Isoelectric point5.0801
Protein length626 amino acids
Orthologs
M. tuberculosis H37RvRv0014c
M. tuberculosis MTBC0mtbc0_000018
Cross-references
UniProtP0A5S5
UniProtKB/TrEMBLX2BDS6, P0A5S5
General annotation
TypeCDS
FunctionUnknown
ProductTRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE B PKNB (PROTEIN KINASE B) (STPK B)
CommentsMb0014c, pknB, len: 626 aa. Equivalent to Rv0014c,len: 626 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 626 aa overlap). pknB, transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), equivalent to MLCB1770_9|T10009 probable serine/threonine-specific protein kinase from Mycobacterium leprae (622 aa), FASTA scores: opt: 3600,E(): 0, (86.4% identity in 626 aa overlap). Also similar (highly similar in N-terminus) to others e.g. T36717 from Streptomyces coelicolor (673 aa); NP_389459.1|NC_000964 from Bacillus subtilis (648 aa); NP_465345.1|NC_003210 from Listeria monocytogenes (655 aa); E235741 protein kinase pknB (315 aa), FASTA scores: opt: 1839, E(): 0,(90.8 identity in 305 aa overlap); etc. Contains PS00107 Protein kinases ATP-binding region signature, and PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation on serine/threonine residues.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS1558917469-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0014c|pknB
MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKVLTDAERTSLLSSAAGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVAVVAVLAVLTVVVTIAINTFGGITRDVQVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHVIGTDPAANTSVSAGDEITVNVSTGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSPSTPELVGKVIGTNPPANQTSAITNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPPAGTTVPVDSVIELQVSKGNQFVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQHNRVVYQNPPAGTGVNRDGIITLRFGQ
Bibliography
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