Gene Mb0015c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE A PKNA (PROTEIN KINASE A) (STPK A) |
| Comments | Mb0015c, pknA, len: 431 aa. Equivalent to Rv0015c,len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 431 aa overlap). pknA, transmembrane serine/threonine-protein kinase (EC 2.7.1.-),magnesium/manganese dependent (see citations below),equivalent to MLCB1770_10|NP_301143.1|NC_002677 putative serine/threonine protein kinase from Mycobacterium leprae (437 aa), FASTA scores: opt: 1883, E(): 0, (72.1% identity in 434 aa overlap). And also highly similar to other kinases from Mycobacterium leprae e.g. MLCB1770_10 from Mycobacterium leprae (437 aa). Also similar to PKNA_MYCLE protein kinase (253 aa), FASTA scores: opt: 1525, E(): 0,(95.0% identity in 242 aa overlap); etc. Also highly similar in part to others e.g. N-terminus of NP_243370.1|NC_002570 from Bacillus halodurans (664 aa); N-terminus of T36717 from Streptomyces coelicolor (673 aa); etc. Also similar to others from Mycobacterium tuberculosis: MTCY10H4_15, MTV021_9, MTCY28_5,MTCY4C12_28, MTCY50_16, MTCY8D9_8, MTCY49_28, MTCY4C12_30,MTCY28_9, etc. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. It has been shown that sodium orthovanadate inhibits the activity of the enzyme in vitro. |
| Functional category | - |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 17466 | 18761 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0015c|pknA
MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRPSQTPPPGRAAPAAIPSGTTARVAANSAGRTAASRRSRPATGGHRPPRRTFSSGQRALLWAAGVLGALAIIIAVLLVIKAPGDNSPQQAPTPTVTTTGNPPASNTGGTDASPRLNWTERGETRHSGLQSWVVPPTPHSRASLARYEIAQ
Bibliography
No article yet recorded
