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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductPUTATIVE SECRETED PROTEIN P60-RELATED PROTEIN [FIRST PART]
CommentsMb0024, -, len: 277 aa. Equivalent to 5' end of Rv0024, len: 281 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 192 aa overlap). Putative secreted protein, p60 homologue, similar in part to others and relatives proteins e.g. P60_LISIV|Q01837 protein p60 precursor (invasion-associated protein) from Listeria ivanovii (524 aa), FASTA scores: opt: 245, E(): 1.5e-08, (37.0% identity in 100 aa overlap); CAB92656.1|AL356832 putative NPL/P60 family secreted protein from Streptomyces coelicolor (347 aa) ; etc. Similar to Mycobacterium tuberculosis proteins Rv1477,Rv1478, Rv1566c, Rv2190c. And several homologues in Streptomyces coelicolor e.g. AL049497|SC6G10_8|T35517 probable secreted protein (338 aa), FASTA scores: opt: 399, E(): 9.8e-18, (34.9% identity in 292 aa overlap). COULD BELONG TO THE E. COLI NLPC / LISTERIA P60 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0024 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0024 into 2 parts, Mb0024 and Mb0025.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS2834329176+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0024|Mb0024
MNYSEVELLSRAHQLFAGDSRRPGLDAGTTPYGDLLSRAADLNVGAGQRRYQLAVDHSRAALLSAARTDAAAGAVITGAQRDRAWARRSTGTVLDEARSDTTVTAVMPIAQREAIRRRVARLRAQRAHVLTARRRARRHLAALRALRYRVAHGPGVALAKLRLPSPSGRAGIAVHAALSRLGRPYVWGATGPTSSTVPVWSSGPTPRRVFTWIAPPINRSTRGSRCRAHRSGRAIWSSRTPGTCSWRSATIWSSRRPMRARRFGSARWATTCRFGDR
      
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