Gene Mb0047c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameino1
Gene length1104 bp
IdentifierMb0047c
Location 50005 bp
Protein summary information
Molecular mass39994.5 Da
Isoelectric point4.7349
Protein length367 amino acids
Orthologs
M. tuberculosis H37RvRv0046c
M. tuberculosis MTBC0mtbc0_000051
Cross-references
UniProtP59967
UniProtKB/TrEMBLX2BDV5, P59967
General annotation
TypeCDS
FunctionUnknown
ProductMYO-INOSITOL-1-PHOSPHATE SYNTHASE INO1 (Inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (Glucose 6-phosphate cyclase) (Glucocycloaldolase)
CommentsMb0047c, ino1, len: 367 aa. Equivalent to Rv0046c,len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 367 aa overlap). ino1 (alternate gene name: tbINO), myo-inositol-1-phosphate synthase (EC 5.5.1.4) (see citations below), equivalent to Q57240|Y046_MYCLE|U00015_14|G466956|B1620_F3_113 HYPOTHETICAL 40.3 KDA PROTEIN from Mycobacterium leprae (369 aa), FASTA scores: opt: 2221, E(): 0, (91.8% identity in 366 aa overlap). N-terminus similar to N-terminus of myo-inositol-1-phosphate synthases e.g. INO1_SPIPO|P42803 myo-inositol-1-phosphate synthase (510 aa), FASTA scores: opt: 144, E(): 0.021, (25.2% identity in 365 aa overlap); CAC21218.1|AJ401007 myo-inositol 1P synthase from Thermotoga sp. SG1 (335 aa); etc. Also highly similar to other hypothetical proteins e.g. AL049826|SCH24_21c hypothetical protein from Streptomyces coelicolor (360 aa), FASTA scores: opt: 1790, E(): 0, (77.8% identity in 360 aa overlap); AE000881_1 conserved protein from M. thermoautotrophicus (368 aa); etc.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS5000551108-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0047c|ino1
MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTSTVPGLMHVRFGPYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTNVIVQRGPTLDGIGKYYADTIELSDAEPVDVVQALKEAKVDVLVSYLPVGSEEADKFYAQCAIDAGVAFVNALPVFIASDPVWAKKFTDAGVPIVGDDIKSQVGATITHRVLAKLFEDRGVQLDRTMQLNVGGNMDFLNMLERERLESKKISKTQAVTSNLKREFKTKDVHIGPSDHVGWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPASAYLMKSPPEQLPDDIARAQLEEFIIG
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