Gene Mb0067c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameicd2
Gene length2238 bp
IdentifierMb0067c
Location 72301 bp
Protein summary information
Molecular mass82536.0 Da
Isoelectric point5.0228
Protein length745 amino acids
Orthologs
M. tuberculosis H37RvRv0066c
M. tuberculosis MTBC0mtbc0_000073
Cross-references
UniProtA0A1R3XWE0
InterProIPR004436, IPR024084
UniProtKB/TrEMBLQ7U2X6
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD2 (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP)
CommentsMb0067c, icd2, len: 745 aa. Equivalent to Rv0066c,len: 745 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 745 aa overlap). Probable icd2,isocitrate dehydrogenase NADP-dependant (EC 1.1.1.42),equivalent to NP_302705.1|NC_002677 isocitrate dehydrogenase [NADP] from Mycobacterium leprae (746 aa). Also highly similar to many members of the monomeric-type family of IDH e.g. NP_251314.1|NC_002516 isocitrate dehydrogenase from Pseudomonas aeruginosa (741 aa); IDH_AZOVI|P16100 isocitrate dehydrogenase (nadp) from Azotobacter vinelandii (741 aa), FASTA scores: opt: 3106,E(): 0, (61.4% identity in 735 aa overlap); NP_230786.1|NC_002505 isocitrate dehydrogenase [Vibrio cholerae (741 aa); etc. BELONGS TO THE MONOMERIC-TYPE FAMILY OF IDH.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS7230174538-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0067c|icd2
MSAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAGIKIEASDISVAARILAEFPDYLTEEQRVPDNLAELGRLTQLPDTNIIKLPNISASVPQLVAAIKELQDKGYAVPDYPADPNTDQEKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKHPHSMGEWSMASRTHVAHMRHGDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPLDDGDVIDSMFMSKKALCDFYEEQMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIFYKDAFAKHQELFDDLGVNVNNGLSDLYSKIESLPASQRDEIIEDLHRCHEHRPELAMVDSARGISNFHSPSDVIVDASMPAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEIINFCKTNGQFDPTTMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDVATGEVLLTENVEAGDIWRMCIVKDAPIRDWVKLAVTRARISGMPVLFWLDPYRPHENELIKKVKTYLKDHDTEGLDIQIMSQVRSMRYTCERLVRGLDTIAATGNILRDYLTDLFPILELGTSAKMLSVVPLMAGGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALGAGFEDIGIKTGNERAKLLGKTLDAAIGKLLDNDKSPSRKTGELDNRGSQFYLAMYWAQELAAQTDDQQLAEHFASLADVLTKNEDVIVRELTEVQGEPVDIGGYYAPDSDMTTAVMRPSKTFNAALEAVQG
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