Gene Mb0071c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | serine hydroxymethyltransferase glya2 (serine methylase 2) (shmt 2) |
| Comments | Mb0071c, glyA2, len: 425 aa. Equivalent to Rv0070c,len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 425 aa overlap). Probable glyA2, serine hydroxymethyltransferase (EC 2.1.2.1), equivalent to NP_302318.1|NC_002677 serine hydroxymethyltransferase from Mycobacterium leprae (426 aa). Also highly similar to many e.g. O86565|GLYA_STRCO SERINE HYDROXYMETHYLTRANSFERASE from Streptomyces coelicolor (420 aa); AAK60516.1|AF327063_1|AF327063 serine hydroxymethyltransferase from Corynebacterium glutamicum (434 aa); GLYA_ECOLI|P00477 serine hydroxymethyltransferase from Escherichia coli (417 aa),FASTA scores: opt: 1462, E(): 0, (54.3% identity in 416 aa overlap); etc. Also highly similar to MTV017_46 from Mycobacterium tuberculosis. Contains PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. BELONGS TO THE SHMT FAMILY. COFACTOR: PYRIDOXAL PHOSPHATE. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 77646 | 78923 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0071c|glyA2
MNTLNDSLTAFDPDIAALIDGELRRQESGLEMIASENYAPLAVMQAQGSVLTNKYAEGYPGRRYYGGCEFVDGVEQLAIDRVKALFGAEYANVQPHSGATANAATMHALLNPGDTILGLSLAHGGHLTHGMRINFSGKLYHATAYEVSKEDYLVDMDAVAEAARTHRPKMIIAGWSAYPRQLDFARFRAIADEVDAVLMVDMAHFAGLVAAGVHPSPVPHAHVVTSTTHKTLGGPRGGIILCNDPAIAKKINSAVFPGQQGGPLGHVIAAKATAFKMAAQPEFAQRQQRCLDGARILAGRLTQPDVAERGIAVLTGGTDVHLVLVDLRDAELDGQQAEDRLAAVDITVNRNAVPFDPRPPMITSGLRIGTPALAARGFSHNDFRAVADLIAAALTATNDDQLGPLRAQVQRLAARYPLYPELHRT
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