Gene Mb0071c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameglyA2
Gene length1278 bp
IdentifierMb0071c
Location 77646 bp
Protein summary information
Molecular mass45453.7 Da
Isoelectric point6.615
Protein length425 amino acids
Cross-references
UniProtQ7U2X3
UniProtKB/TrEMBLX2BDX9, Q7U2X3
General annotation
TypeCDS
FunctionUnknown
Productserine hydroxymethyltransferase glya2 (serine methylase 2) (shmt 2)
CommentsMb0071c, glyA2, len: 425 aa. Equivalent to Rv0070c,len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 425 aa overlap). Probable glyA2, serine hydroxymethyltransferase (EC 2.1.2.1), equivalent to NP_302318.1|NC_002677 serine hydroxymethyltransferase from Mycobacterium leprae (426 aa). Also highly similar to many e.g. O86565|GLYA_STRCO SERINE HYDROXYMETHYLTRANSFERASE from Streptomyces coelicolor (420 aa); AAK60516.1|AF327063_1|AF327063 serine hydroxymethyltransferase from Corynebacterium glutamicum (434 aa); GLYA_ECOLI|P00477 serine hydroxymethyltransferase from Escherichia coli (417 aa),FASTA scores: opt: 1462, E(): 0, (54.3% identity in 416 aa overlap); etc. Also highly similar to MTV017_46 from Mycobacterium tuberculosis. Contains PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. BELONGS TO THE SHMT FAMILY. COFACTOR: PYRIDOXAL PHOSPHATE.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS7764678923-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0071c|glyA2
MNTLNDSLTAFDPDIAALIDGELRRQESGLEMIASENYAPLAVMQAQGSVLTNKYAEGYPGRRYYGGCEFVDGVEQLAIDRVKALFGAEYANVQPHSGATANAATMHALLNPGDTILGLSLAHGGHLTHGMRINFSGKLYHATAYEVSKEDYLVDMDAVAEAARTHRPKMIIAGWSAYPRQLDFARFRAIADEVDAVLMVDMAHFAGLVAAGVHPSPVPHAHVVTSTTHKTLGGPRGGIILCNDPAIAKKINSAVFPGQQGGPLGHVIAAKATAFKMAAQPEFAQRQQRCLDGARILAGRLTQPDVAERGIAVLTGGTDVHLVLVDLRDAELDGQQAEDRLAAVDITVNRNAVPFDPRPPMITSGLRIGTPALAARGFSHNDFRAVADLIAAALTATNDDQLGPLRAQVQRLAARYPLYPELHRT
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