Gene Mb0090
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | possible formate hydrogenase hyce (fhl) |
| Comments | Mb0090, hycE, len: 492 aa. Equivalent to Rv0087,len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 492 aa overlap). Possible hycE (alternate gene name: hevE), formate hydrogenlyase (EC 1.-.-.-), similar to others e.g. HYCE_ECOLI|P16431 formate hydrogenlyase subunit 5 from Escherichia coli (569 aa),FASTA scores: opt: 680, E(): 1.8e-38, (31.2% identity in 449 aa overlap); NP_457243.1|NC_003198 formate hydrogenlyase subunit 5 from Salmonella enterica subsp. enterica serovar Typhi (569 aa); NP_275541.1|NC_000916 formate hydrogenlyase subunit 5 from Methanothermobacter thermautotrophicus (370 aa); etc. Also some similarity with NUOD_ECOLI|P33600 NADH dehydrogenase I chain D from Escherichia coli (407 aa), FASTA scores: opt: 245, E(): 8.9e-10, (24.5% identity in 368 aa overlap). BELONGS TO THE COMPLEX I 49 kDa SUBUNIT FAMILY. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 95449 | 96927 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0090|hycE
MMSASWLRHRVSERGLIATAEQLWADSFRLALVAAHDDGDSLRVVYLFLAGYPDRRVELEYVVPADNPEIRSLAYLSFPAGRFEREMADLYGIRPVGHPKPRRLVRHAHWPDWHPMRTDAGPAPEFTDTGAFPFLAVEGPGVYEIPVGPVHAGLIEPGHFRFSVAGETIVRLKARLWFVHRGIEKLFHGRPATAAVDLAERISGDTSAAHALAHSLAIEDALGIELPHEIHRLRALIVELERLYNHAADLGALANDVGYSLANAHAQRIRENLLRRNAAVTGHRLLRGAIRAGGVALRALPDTDELAALAVDLAEVATLTLANSVVYDRFAGTAVLHPDDASALGCLGYVARASGLRSDARVEHPTIVLPITEIGAPDGDVLARYTVRRDEFAASAALAQHIVESHTGPIEYAATLHPVGAPSSGIGIVEGWRGTIVHRVEIDVDGRITRAKVVDPSWFNWPALPVAMADTIVPDFPLANKSFNQSYAGNDL
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