Gene Mb0102 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namefadD10
Gene length1623 bp
IdentifierMb0102
Location 108192 bp
Protein summary information
Molecular mass56589.7 Da
Isoelectric point4.8247
Protein length540 amino acids
Cross-references
UniProtA0A1R3XUC2
InterProIPR000873, IPR020845, IPR025110
UniProtKB/TrEMBLQ7U2V0
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE FATTY-ACID-COA LIGASE FADD10 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)
CommentsMb0102, fadD10, len: 540 aa. Equivalent to Rv0099,len: 540 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 540 aa overlap). Possible fadD10,fatty-acid-CoA synthetase (EC 6.2.1.-), equivalent to MLACEA_4|Q50176 LONG CHAIN FATTY ACID-COA LIGASE from Mycobacterium leprae (532 aa), FASTA scores: opt: 2580,E(): 0, (74.6% identity in 531 aa overlap). Also similar to many e.g. BAB69379.1|AB070955 long-chain fatty acid--CoA ligase from Streptomyces avermitilis (518 aa); NP_419782.1|NC_002696 putativ long-chain-fatty-acid--CoA ligase from Caulobacter crescentus (530 aa); NP_435326.1|NC_003037 probable long chain fatty acid CoA ligase from Sinorhizobium meliloti (508 aa); etc. Also similar to ACSA_BACSU|P39062 acetyl-coenzyme A synthetase from Bacillus subtilis (572 aa), FASTA scores: opt: 415,E(): 9.8e-20, (27.1% identity in 539 aa overlap). Contains PS00455 putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS108192109814+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0102|fadD10
MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNLPIAAIERFCQITDPAAALVAPGSKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASLAGNADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLPATHIGGLWWILTCLMHGGLCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLSETGCTALCLPTDDGSIVKIEAGAVGRPYPGVDVYLAATDGIGPTAPGAGPSASFGTLWIKSPANMLGYWNNPERTAEVLIDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGALVGLAVVASAELDESAARALKHTIAARFRRESEPMARPSTIVIVTDIPRTQSGKVMRASLAAAATADKARVVVRG
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