Gene Mb0204c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namezmp1
Gene length1992 bp
IdentifierMb0204c
Location 234712 bp
Protein summary information
Molecular mass73913.7 Da
Isoelectric point4.8422
Protein length663 amino acids
Orthologs
M. tuberculosis H37RvRv0198c
M. tuberculosis MTBC0mtbc0_000212
Cross-references
UniProtA0A1R3XUL2
InterProIPR000718, IPR008753, IPR018497, IPR024079
UniProtKB/TrEMBLQ7U2L2
General annotation
TypeCDS
FunctionUnknown
Productprobable zinc metalloprotease zmp1
CommentsMb0204c, -, len: 663 aa. Equivalent to Rv0198c,len: 663 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 663 aa overlap). Probable zinc metalloprotease (EC 3.4.24.-), equivalent to Z95398|MLCL622.12c from Mycobacterium leprae (667 aa),FASTA scores: opt: 3710, E(): 0, (80.8 % identity in 667 aa overlap). Also similar to many other metalloproteases e.g. members of the eukaryotic neprilysin family: P08473|NEP_HUMAN NEPRILYSIN (EC 3.4.24.11) (749 aa), FASTA scores: opt: 872, E(): 0, (31.1% identity in 692 aa overlap); Q07744|PEPO_LACLA NEUTRAL ENDOPEPTIDASE from Lactococcus lactis (626 aa), FASTA scores: opt: 862, E(): 0, (30.0% identity in 654 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. BELONGS TO PEPTIDASE FAMILY M13 (ZINC METALLOPROTEASE); ALSO KNOWN AS THE NEPRILYSIN SUBFAMILY.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS234712236703-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0204c|zmp1
MTLAIPSGIDLSHIDADARPQDDLFGHVNGRWLAEHEIPADRATDGAFRSLFDRAETQVRDLIIQASQAGAAVGTDAQRIGDLYASFLDEEAVERAGVQPLHDELATIDSAADATELAAALGTLQRAGVGGGIGVYVDTDSKDSTRYLVHFTQSGIGLPDESYYRDEQHAAVLAAYPGHIARMFGLVYGGESRDHAKTADRIVALETKLADAHWDVVKRRDADLGYNLRTFAQLQTEGAGFDWVSWVTALGSAPDAMTELVVRQPDYLVTFASLWASVNVEDWKCWARWRLIRARAPWLTRALVAEDFEFYGRTLTGAQQLRDRWKRGVSLVENLMGDAVGKLYVQRHFPPDAKSRIDTLVDNLQEAYRISISELDWMTPQTRQRALAKLNKFTAKVGYPIKWRDYSKLAIDRDDLYGNVQRGYAVNHDRELAKLFGPVDRDEWFMTPQTVNAYYNPGMNEIVFPAAILQPPFFDPQADEAANYGGIGAVIGHEIGHGFDDQGAKYDGDGNLVDWWTDDDRTEFAARTKALIEQYHAYTPRDLVDHPGPPHVQGAFTIGENIGDLGGLSIALLAYQLSLNGNPAPVIDGLTGMQRVFFGWAQIWRTKSRAAEAIRRLAVDPHSPPEFRCNGVVRNVDAFYQAFDVTEDDALFLDPQRRVRIWN
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