Gene Mb0249 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namefadA2
Gene length1323 bp
IdentifierMb0249
Location 290495 bp
Protein summary information
Molecular mass46107.2 Da
Isoelectric point6.6351
Protein length440 amino acids
Orthologs
M. tuberculosis MTBC0mtbc0_000259
M. tuberculosis H37RvRv0243
Cross-references
UniProtA0A1R3XUX8
InterProIPR002155, IPR016038, IPR016039, IPR020610, IPR020616, IPR020617
UniProtKB/TrEMBLQ7U2H1
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)
CommentsMb0249, fadA2, len: 440 aa. Equivalent to Rv0243,len: 440 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 440 aa overlap). Probable fadA2,acetyl-CoA acyltransferase (3-acyl-CoA thiolase) (EC 2.3.1.16), equivalent, but shorter 17 aa, to AL022486|MLCB1883_14T44879 acetyltransferase from Mycobacterium leprae (457 aa), FASTA scores: opt: 250 7,E(): 0, (87.6% identity in 435 aa overlap). Also highly similar to many e.g. G83046|PA478 probable acyl-CoA thiolase from Pseudomonas aeruginosa (425 aa); AB77293.1|AL160312 putative ketoacyl CoA thiolase from Streptomyces coelicolor (428 aa); P76503|7449731|YFCY_ECOLI|D65007|B2342 PROBABLE 3-KETOACYL-COA THIOLASE (ACETYL-COA ACYLTRANSFERASE) (BETA-KETOTHIOLASE) from Escherichia coli strain K-12 (436 aa), FASTA scores: opt: 914, E(): 0, (38.2% identity in 434 aa overlap); P55084|ECHB_HUMAN MITOCHONDRIAL TRIFUNCTONAL ENZYME (474 aa), FASTA scores: opt: 881, E(): 0, (37.7 identity in 451 aa overlap). Contains PS00099 Thiolases active site. BELONGS TO THE THIOLASE FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS290495291817+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0249|fadA2
MAPAAKNTSQTRRRVAVLGGNRIPFARSDGAYADASNQDMFTAALSGLVDRFGLAGERLDMVVGGAVLKHSRDFNLMRECVLGSELSPYTPAFDLQQACGTGLQAAIAAADGIAAGRYEVAAAGGVDTTSDPPIGLGDDLRRTLLKLRRSRSNVQRLKLVGTLPASLGVEIPANSEPRTGLSMGEHAAVTAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVSPFLGLYRDDNLRPNSSVEKLATLRPVFGVKAGDATMTAGNSTPLTDGASVALLASEQWAEAHSLAPLAYLVDAETAAVDYVNGNDGLLMAPTYAVPRLLARNGLSLQDFDFYEIHEAFASVVLAHLAAWESEEYCKRRLGLDAALGSIDRSKLNVNGSSLAAGHPFAATGGRILAQTAKQLAEKKAAKKGGGPLRGLISICAAGGQGVAAILEA
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