Gene Mb0258 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namenirB
Gene length2562 bp
IdentifierMb0258
Location 301191 bp
Protein summary information
Molecular mass90352.6 Da
Isoelectric point5.2999
Protein length853 amino acids
Orthologues
M. tuberculosisRv0252
Cross-references
UniProtA0A1R3XVV3
InterProIPR001327, IPR005117, IPR006066, IPR006067, IPR007419, IPR012744, IPR013027, IPR017121, IPR023753
UniProtKB/TrEMBLQ7U2G2
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE NITRITE REDUCTASE [NAD(P)H] LARGE SUBUNIT [FAD FLAVOPROTEIN] NIRB
CommentsMb0258, nirB, len: 853 aa. Equivalent to Rv0252,len: 853 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 853 aa overlap). Probable nirB (alternate gene name: nasB), nitrite reductase [NAD(P)H] large subunit (EC 1.6.6.4), flavoprotein containing siroheme and a 2FE-2S iron-sulfur centre. Highly similar to many others bacterial enzymes e.g. P08201|NIRB_ECOLI NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT from Escherichia coli strain K12 (847 aa), FASTA scores: opt: 2775, E(): 0,(49.8% identity in 840 aa overlap); Q06458|NIRB_KLEPN NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT (957 aa), FASTA scores: opt: 2902, E(): 0, (54.2% identity in 827 aa overlap). Contains PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. HOMODIMER WHICH ASSOCIATES WITH NIRD|Rv0253. COFACTORS: FAD; Iron; Siroheme.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS301191303752+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0258|nirB
MPTAGSSRAPAAAREIVVVGHGMVGHRLVEAVRARDADGSLRITVLAEEGDAAYDRVGLTSYTESWDRALLALPGNDYAGDQRVRLLLNTRVTQIDRATKSVVTAAGQRHRYDTLVLATGSYAFVPPVPGHDLPACHVYRTFDDLDAIRAGAQRTLDGGHTDGGVVIGGGLLGLEAANALRQFGLQTHVVEMMPRLMAQQIDEAGGALLARMIADLGIAVHVGTGTESIESVKHSDGSVWARVRLSDGEVIDAGVVIFAAGIRPRDELARAAGLAIGDRGGVLTDLSCRTSDPDIYAVGEVAAIDGRCYGLVGPGYTSAEVVADRLLDGSAEFPEADLSTKLKLLGVDVASFGDAMGATENCLEVVINDAVKRTYAKLVLSDDATTLLGGVLVGDASSYGVLRPMVGAELPGDPLALIAPAGSGAGAGALGVGALPDSAQICSCNNVTKGELKCAIADGCGDVPALKSCTAAGTSCGSCVPLLKQLLEAEGVEQSKALCEHFSQSRAELFEIITATEVRTFSGLLDRFGRGKGCDICKPVVASILASTGSDHILDGEQASLQDSNDHFLANIQKNGSYSVVPRVPGGDIKPEHLILIGQIAQDFGLYTKITGGQRIDLFGARVDQLPLIWQRLVDGGMESGHAYGKAVRTVKSCVGSDWCRYGQQDSVQLAIDLELRYRGLRAPHKIKLGVSGCARECAEARGKDVGVIATEKGWNLYVAGNGGMTPKHAQLLASDLDKETLIRYIDRFLIYYIRTADRLQRTAPWVESLGLDHVREVVCEDSLGLAEEFEAAMQRHVANYKCEWKGVLEDPDKLSRFVSFVNAPDAVDSTVTFTERAGRKVPVSIGIPRVRS
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