Gene Mb0285c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namePE_PGRS3a
Gene length2607 bp
IdentifierMb0285c
Location 331827 bp
Protein summary information
Molecular mass71049.6 Da
Isoelectric point4.6769
Protein length868 amino acids
Cross-references
UniProtA0A1R3XUU3
InterProIPR000084
UniProtKB/TrEMBLQ7U2D8
General annotation
TypeCDS
FunctionUnknown
ProductPE-PGRS FAMILY PROTEIN [FIRST PART]
CommentsMb0285c, PE_PGRS3a, len: 868 aa. Similar to 5' end of Rv0278c, len: 957 aa, from Mycobacterium tuberculosis strain H37Rv, (80.7% identity in 888 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 3849, E(): 0, (67.8% identity in 903 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis, a 2780 bp insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (t-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS331827334433-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0285c|PE_PGRS3a
MSFVIAAPEVIAAAATDLASLESSIAAANAAAAANTTALLAAGADEVSTAVAALFGAHGQAYQALSAQAQAFHAQFTQALTSGGGAYAAAEAAATSPLLAPINEFFLANTGRPLIGNGANGAPGTGADGAPGGWLIGNGGAGGSGAANNAVGGTGGTGGAGGASGLLGSGGAGGAGGVATNTGGIGGAGGTGGNAVLFGAGGAGGASTNTTGGAGGAGGDGGNAGLLFGAAGVGGAGGFALATTASGGAGGAGGAGGMFTDGGVGGVGGKGGFGGAGGAGGNGGLFGAGGTGGAGGTIGAGVAGMGGAGGAGGAGGLFGAGGTGGSGGGGATTGGDGGAGGAGGFGRTTGGIGGTGGNAGLLNGSGGAGGAGGAAITGPGGTGGAGGIPGLIGNGGNGGDGGASVTGTGGNGGAGGNGVQIGNGGNGGSGGTGAAAGKAGLGGLGGQLIGLDGSNAPVSTSVHTLQQAALNVVNEPFQTLTGRPLIGNGANGTPGTGAAGGAGGWLFGNGGNGGHGATNTAATATGGAGGAGGILFGTGGNGGTGGIATGAGGIGGAGGAGGVSLLIGSGGTGGNGGNSIGVAGIGGAGGRGGDAGLLFGAAGTGGHGAAGGVPAGVGGAGGNGGLFANGGAGGAGGFNAAGGNGGNGGLFGTGGTGGAGTNFGAGGNGGNGGLFGAGGTGGAAGSGGSGITTGGGGHGGNAGLLSLGASGGAGGSGGASSLAGGAGGTGGNGALLFGFGGAGGAGGHGGAALTSIQQGGAGGAGGNGGLLFGSAGAGGAGGSGANALGAGTGGTGGDGGHAGVFGNGGDGGAGGFGAGTGGSGGVGGNAVLIGNGGNGGNAGKAGATPGAGGTGGLLLGENGLNGLP
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