Gene Mb0304c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameMb0304c
Gene length1398 bp
IdentifierMb0304c
Location 360760 bp
Protein summary information
Molecular mass51846.1 Da
Isoelectric point5.6676
Protein length465 amino acids
Orthologues
M. tuberculosisRv0296c
Cross-references
UniProtA0A1R3XUX0
InterProIPR000917, IPR017849, IPR017850, IPR024607
UniProtKB/TrEMBLQ7U2C1
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE SULFATASE
CommentsMb0304c, -, len: 465 aa. Equivalent to Rv0296c,len: 465 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 465 aa overlap). Probable sulfatase,possibly an aryl-/steryl-sulfatase (EC 3.1.6.-) or a sulfamidase (sulfohydrolase) (sulphamidase) (EC 3.10.1.-). Similar to various hydrolases e.g. AAG41945.1|AF304053_1|AF304053 heparan N-sulfatase from Mus musculus (502 aa); NP_061292.1|6851181|AAF29460.1|AF153827_1|AF153827 N-sulfoglucosamine sulfohydrolase (sulfamidase) (sulphamidase) from Mus musculus (502 aa); AAG17206.1|AF217203_1|AF217203 heparan sulfate sulfamidase from Canis familiaris (507 aa); P08842|STS_HUMAN|1360652 STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL-SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC) from Homo sapiens (583 aa); ARSB_FELCA|P33727 arylsulfatase B precursor (EC 3.1.6.1) (535 aa), FASTA scores: opt: 231, E(): 1.7e-08, (30.3% identity in 261 aa overlap). Also similarity with 4 others sulfatases in Mycobacterium tuberculosis. Contains sulfatases signature 1 (PS00523). Note that previously known as atsG.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS360760362157-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0304c|Mb0304c
MTSERATGQRENLLIVHWHDLGRYLGVYHHPDVYSPRLDRLAAEGILFTRAHATAPLCTPSRGSLFTGRYPQSNGLVGLAHHGWEYRTGVQTLPQLLSESGWYSALFGMQHETSYPKRLGFDEFDVSNSYCEYVVAKAQDWLHNRVPALDGQRFLLTAGFFETHRPYPHERYRPADSAAVELPDYLPDTPEVRQDVAEFYGSIATADEAVGRLLDTLADTGLDASTWVVFVTDHGPAFPRAKSTLYDAGTGIALIIRPPTRRAMAPRVYDELFSGVDLVPTLLDLLRLEVPADVEGVSHAPALLAPDTENAAVRDHVYTAKTYHDSFDPIRAIRTKEYSYIENYAPRPLLDLPWDIQESPAGMAVAPLVKAPRPQRELYDLRADPTETNNLLAGDDSTQGVAAIAADLAVRLHDWRQRTADVIPSDFAGSRIAERYTETYLRIHRKTPTGRSAIAADRGIDEHCS
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