Gene Mb0334c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namecyp135A1
Gene length1350 bp
IdentifierMb0334c
Location 393726 bp
Protein summary information
Molecular mass50036.8 Da
Isoelectric point10.2917
Protein length449 amino acids
Cross-references
UniProtA0A1R3XV04
InterProIPR001128, IPR002401, IPR017972
UniProtKB/TrEMBLQ7U292
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE CYTOCHROME P450 135A1 CYP135A1
CommentsMb0334c, cyp135A1, len: 449 aa. Equivalent to Rv0327c, len: 449 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 449 aa overlap). Possible cyp135A1, cytochrome P450 (EC 1.14.-.-), similar to cytochrome P-450 monoxygenases and other cytochrome P-450 related enzymes e.g. FQ12609 PUTATIVE P450 MONOOXYGENASE (EC 1.14.14.1) (506 aa), FASTA scores: opt: 276, E() : 1.7e-11, (27.9% identity in 433 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. MTV039.06|Rv0568 PUTATIVE CYTOCHROME P450 (472 aa); MTCI5.10 cytochrome p450 FASTA score: (30.4% identity in 434 aa overlap). Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). BELONGS TO THE CYTOCHROME P450 FAMILY. Alternative start possible at 33706 but no RBS.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS393726395075-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0334c|cyp135A1
MASTLTTGLPPGPRLPRYLQSVLYLRFREWFLPAMHRKYGDVFSLRVPPYADNLVVYTRPEHIKEIFAADPRSLHAGEGNHILGFVMGEHSVLMTDEAEYARMRSLLMPAFTRAALRGYRDMIASVAREHITRWRPHATINSLDHMNALTLDIILRVVFGVTDPKVKAELTSRLQQIINIHPAILAGVPYPSLKRMNPWKRFFHNQTKIDEILYREIASRRIDSDLTARTDVLSRLLQTKDTPTKPLTDAELRDQLITLLLAGHETTAAALSWTLWELAHAPEIQSQVVWAAVGGDDGFLEAVLKEGMRRHTVIASTARKVTAPAEIGGWRLPAGTVVNTSILLAHASEVSHPKPTEFRPSRFLDGSVAPNTWLPFGGGVRRCLGFGFALTEGAVILQEIFRRFTITAAGPSKGETPLVRNITTVPKHGAHLRLIPQRRLGGLGDSDPP
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