Gene Mb0361 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehspR
Gene length381 bp
IdentifierMb0361
Location 424668 bp
Protein summary information
Molecular mass14126.2 Da
Isoelectric point10.9294
Protein length126 amino acids
Orthologues
M. tuberculosisRv0353
Cross-references
UniProtA0A1R3XV98
InterProIPR000551, IPR009061
UniProtKB/TrEMBLQ7U271
General annotation
TypeCDS
FunctionUnknown
Productprobable heat shock protein transcriptional repressor hspr (merr family)
CommentsMb0361, hspR, len: 126 aa. Equivalent to Rv0353,len: 126 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 126 aa overlap). Probable hspR, heat shock regulatory protein, merR family, highly similar to others e.g. HspR|P40183 heat shock regulatory protein from Streptomyces coelicolor (151 aa), FASTA scores: E(): 4.9e-22, (55.7% identity in 140 aa overlap), that binds to three inverted repeats (IR1-IR3) in the promoter region of the dnaK operon. Has possible coiled coil region in C-terminal half. BELONGS TO THE MERR FAMILY OF TRANSCRIPTIONAL REGULATORS.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS424668425048+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0361|hspR
MAKNPKDGESRTFLISVAAELAGMHAQTLRTYDRLGLVSPRRTSGGGRRYSLHDVELLRQVQHLSQDEGVNLAGIKRIIELTSQVEALQSRLQEMAEELAVLRANQRREVAVVPKSTALVVWKPRR
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