Gene Mb0422c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namethiE
Gene length669 bp
IdentifierMb0422c
Location 501369 bp
Protein summary information
Molecular mass23271.3 Da
Isoelectric point6.1205
Protein length222 amino acids
Cross-references
UniProtP66917
UniProtKB/TrEMBLX2BEY7, P66917
General annotation
TypeCDS
FunctionUnknown
Productthiamine-phosphate pyrophosphorylase thie (tmp pyrophosphorylase) (tmp-ppase) (thiamine-phosphate synthase)
CommentsMb0422c, thiE, len: 222 aa. Equivalent to Rv0414c,len: 222 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 222 aa overlap). Probable thiE,thiamin phosphate pyrophosphorylase (EC 2.5.1.3),equivalent to Q9ZBL5|AL035159|MLCB1450_17 PROBABLE THIAMINE-PHOSPHATE PYROPHOSPHORYLASE from Mycobacterium leprae (235 aa), FASTA scores: opt: 1095, E(): 0, (78.0% identity in 223 aa overlap). Also similar to others e.g. T34974|5689976|CAB52013.1|AL109663 probable thiamin phosphate pyrophosphorylase from Streptomyces coelicolor (223 aa); THIE_ECOLI|P30137 thie protein from Escherichia coli strain K12 (211 aa), FASTA scores: opt: 275, E(): 7.8e-12, (37.8% identity in 196 aa overlap); etc. BELONGS TO THE TMP-PPASE FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS501369502037-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0422c|thiE
MHESRLASARLYLCTDARRERGDLAQFAEAALAGGVDIIQLRDKGSPGELRFGPLQARDELAACEILADAAHRYGALFAVNDRADIARAAGADVLHLGQRDLPVNVARQILAPDTLIGRSTHDPDQVAAAAAGDADYFCVGPCWPTPTKPGRAAPGLGLVRVAAELGGDDKPWFAIGGINAQRLPAVLDAGARRIVVVRAITSADDPRAAAEQLRSALTAAN
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