Gene Mb0423 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namethiO
Gene length1023 bp
IdentifierMb0423
Location 502167 bp
Protein summary information
Molecular mass36562.8 Da
Isoelectric point6.6019
Protein length340 amino acids
Orthologs
M. tuberculosis H37RvRv0415
M. tuberculosis MTBC0mtbc0_000435
Cross-references
UniProtA0A1R3XVA6
InterProIPR006076, IPR012727
UniProtKB/TrEMBLQ7U217
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE THIAMINE BIOSYNTHESIS OXIDOREDUCTASE THIO
CommentsMb0423, thiO, len: 340 aa. Equivalent to Rv0415,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 340 aa overlap). Possible thiO,thiamine biosynthesis oxidoreductase (EC 1.-.-.-),equivalent to T44739|4154054|CAA22708.1|AL035159|MLCB1450.24 hypothetical protein from Mycobacterium leprae (340 aa),FASTA scores: opt: 1867, E(): 0, (82.0% identity in 338 aa overlap). Shows some similarity to other thiO proteins e.g. THIO_RHIET|O34292 Putative thiamine biosynthesis oxidoreductase from Rhizobium etli plasmid pb (327 aa) (see citation below); AAG31046.1|AF264948_8|THIO putative amino acid oxidase flavoprotein ThiO from Erwinia amylovora (349 aa); NP_106392.1|14025578|BAB52178.1|AP003007|THIO THIAMINE BIOSYNTHESIS OXIDOREDUCTASE THIO from Mesorhizobium loti (333 aa); etc.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS502167503189+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0423|thiO
MASDLHTGSLAVIGGGVIGLSVARRAAQAGWPVRVHRSDERGASWVAGGMLAPHSEGWPGEERLLRLGLQSLRLWREGSFLDGLGPQLVTAHESLVVAVDRADVADLRTVADWLSAQGHPVIWESAARDVEPLLAQGIRHGFRAPTELAVDNRALLDVLCRDCERLGVRWSSQVSSLSDVDAHTVVIANGIDAPALWPGLPIRPVKGEVLRLRWRPGCMPLPQRVIRARVRGRQVYLVPRSDGVVVGATQYEHGRDTAPVVSGVRDLLDDACTVLPALGEYELAECEAGLRPMTPDNLPLVQRLDSRTLVAAGHGRSGFLLAPWTAEQIVSELVSVGAAS
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