Gene Mb0476 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameicl
Gene length1287 bp
IdentifierMb0476
Location 558546 bp
Protein summary information
Molecular mass47086.6 Da
Isoelectric point4.7919
Protein length428 amino acids
Orthologs
M. tuberculosis H37RvRv0467
M. tuberculosis MTBC0mtbc0_000491
Cross-references
UniProtP0A5H4
UniProtKB/TrEMBLX2BF40, P0A5H4
General annotation
TypeCDS
FunctionUnknown
ProductISOCITRATE LYASE ICL (ISOCITRASE) (ISOCITRATASE)
CommentsMb0476, icl, len: 428 aa. Equivalent to Rv0467,len: 428 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 428 aa overlap). icl (previously known as aceA), isocitrate lyase (EC 4.1.3.1) (see citations below), highly similar to many, closest to Z29367|RFISCILY_1 from R. fascians (429 aa), FASTA scores: opt: 2359, E(): 0, (80.7% identity in 429 aa overlap). BELONGS TO THE ISOCITRATE LYASE FAMILY.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS558546559832+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0476|icl
MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGSTEEGQFH
Bibliography
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