Gene Mb0500 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namesenX3
Gene length1233 bp
IdentifierMb0500
Location 580370 bp
Protein summary information
Molecular mass44824.7 Da
Isoelectric point6.4423
Protein length410 amino acids
Cross-references
UniProtP0A601
UniProtKB/TrEMBLX2BF71, P0A601
General annotation
TypeCDS
FunctionUnknown
ProductPUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3
CommentsMb0500, senX3, len: 410 aa. Equivalent to Rv0490,len: 410 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 410 aa overlap). Putative senX3,two-component sensor histidine kinase (EC 2.7.3.-),transmembrane protein (see citations below), equivalent to O07129|SEX3_MYCBO SENSOR-LIKE HISTIDINE KINASE SENX3 from Mycobacterium bovis BCG (410 aa), FASTA scores: E(): 0,(99.5% identity in 410 aa overlap); and highly similar to P54883|SEX3_MYCLE|SENX3 SENSOR-LIKE HISTIDINE KINASE from Mycobacterium leprae (443 aa), FASTA score: (83.8% identity in 408 aa overlap). Also highly similar, except in N-terminus, to CAC31957.1|AL583925 probable two-component system sensor histidine kinase from Mycobacterium leprae (441 aa). Also highly similar to sensor kinase proteins from other organisms e.g. CAB77323.1|AL160331 putative sensor kinase protein from Streptomyces coelicolor (426 aa).
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS580370581602+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0500|senX3
MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWSGITVSQMLQCIVTLMPLGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRAARQALGGEDVEFDLSPRKRSATGRSGLSVHGHARLLSEEDRRFAVVFVHDQSDYARMEAARRDFVANVSHELKTPVGAMALLAEALLASADDSETVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLPNMTDVDVDTIVSEAISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTALANLVSNAIAYSPRGSLVSISRRRRGANIEIAVTDRGIGIAPEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALIEAYHDDERPEQAREPELRSNRSQREEELSR
Bibliography
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