Gene Mb0521 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehemA
Gene length1407 bp
IdentifierMb0521
Location 601592 bp
Protein summary information
Molecular mass49361.4 Da
Isoelectric point6.5152
Protein length468 amino acids
Orthologs
M. tuberculosis H37RvRv0509
M. tuberculosis MTBC0mtbc0_000537
Cross-references
UniProtP64329
UniProtKB/TrEMBLX2BFA0, P64329
General annotation
TypeCDS
FunctionUnknown
Productprobable glutamyl-trna reductase hema (glutr)
CommentsMb0521, hemA, len: 468 aa. Equivalent to Rv0509,len: 468 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 468 aa overlap). Probable hemA,glutamyl-tRNA reductase (EC 1.2.1.-), equivalent to HEM1_MYCLE|P46724 GLUTAMYL-TRNA REDUCTASE from Mycobacterium leprae (467 aa), FASTA scores: opt: 2377,E(): 0, (82.3% identity in 463 aa overlap). Also highly similar (sometimes in part) to others e.g. Q9WX15|HEM1_STRCO GLUTAMYL-TRNA REDUCTASE from Streptomyces coelicolor (581 aa); P16618|HEM1_BACSU|HEMA GLUTAMYL-TRNA REDUCTASE from Bacillus subtilis (455 aa); etc. Contains PS00747 Glutamyl-tRNA reductase signature. BELONGS TO THE GLUTAMYL-TRNA REDUCTASE FAMILY.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS601592602998+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0521|hemA
MSVLLFGVSHRSAPVVVLEQLSIDESDQVKIIDRVLASPLVTEAMVLSTCNRVEVYAVVDAFHGGLSVIGQVLAEHSGMSMGELTKYAYVRYSEAAVEHLFAVASGLDSAVIGEQQVLGQVRRAYAVAESNRTVGRVLHELAQRALSVGKRVHSETAIDAAGASVVSVALGMAERKLGSLAGTTAVVIGAGAMGALSAVHLTRAGVGHIQVLNRSLSRAQRLARRIRESGVPAEALALDRLANVLADADVVVSCTGAVRPVVSLADVHHALAAARRDEATRPLVICDLGMPRDVDPAVARLPCVWVVDVDSVQHEPSAHAAAADVEAARHIVAAEVASYLVGQRMAEVTPTVTALRQRAAEVVEAELLRLDNRLPGLQSVQREEVARTVRRVVDKLLHAPTVRIKQLASAPGGDSYAEALRELFELDQTAVDAVATAGELPVVPSGFDAESRRGGGDMQSSPKRSPSN
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