Gene Mb0523
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE PORPHOBILINOGEN DEAMINASE HEMC (PBG) (HYDROXYMETHYLBILANE SYNTHASE) (HMBS) (PRE-UROPORPHYRINOGEN SYNTHASE) |
| Comments | Mb0523, hemC, len: 309 aa. Equivalent to Rv0510,len: 309 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 309 aa overlap). Probable hemC,hydroxymethylbilane synthase (porphobilinogen deaminase) (EC 4.3.1.8), equivalent to HEM3B|Q49808|HEM3_MYCLE PORPHOBILINOGEN DEAMINASE from Mycobacterium leprae (315 aa), FASTA scores: opt: 889, E(): 0, (88.1% identity in 159 aa overlap). Also highly similar to others e.g. Q9WX16|HE31_STRCO PROBABLE PORPHOBILINOGEN DEAMINASE from Streptomyces coelicolor (319 aa); Q9L6Q2|HEM3_SALTY PORPHOBILINOGEN DEAMINASE from Salmonella typhimurium (313 aa); etc. BELONGS TO THE HMBS FAMILY. COFACTOR: COVALENTLY BINDS A DIPYRROMETHANE COFACTOR TO WHICH THE PORPHOBILINOGEN SUBUNITS ARE ADDED. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 603008 | 603937 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0523|hemC
MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGARELMWGVRH
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