Gene Mb0577 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namegrcC1
Gene length1008 bp
IdentifierMb0577
Location 654014 bp
Protein summary information
Molecular mass35560.3 Da
Isoelectric point4.7247
Protein length335 amino acids
Orthologs
M. tuberculosis H37RvRv0562
M. tuberculosis MTBC0mtbc0_000591
Cross-references
UniProtA0A1R3XWR5
InterProIPR000092, IPR008949, IPR017446
UniProtKB/TrEMBLQ7U1R8
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE)
CommentsMb0577, grcC1, len: 335 aa. Equivalent to Rv0562,len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 335 aa overlap). Probable grcC1,polyprenyl diphosphate synthetase (EC 2.5.1.-), equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta (EC 2.5.1.30) or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348aa), FASTA scores: opt: 599, E(): 4e-31,(33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE (325 aa); Rv3383c,Rv3398c, etc. Contains PS00444 Polyprenyl synthetases signature 2. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS654014655021+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0577|grcC1
MRTPATVVAGVDLGDAVFAAAVRAGVARVEQLMDTELRQADEVMSDSLLHLFNAGGKRFRPLFTVLSAQIGPQPDAAAVTVAGAVIEMIHLATLYHDDVMDEAQVRRGAPSANAQWGNNVAILAGDYLLATASRLVARLGPEAVRIIADTFAQLVTGQMRETRGTSENVDSIEQYLKVVQEKTGSLIGAAGRLGGMFSGATDEQVERLSRLGGVVGTAFQIADDIIDIDSESDESGKLPGTDVREGVHTLPMLYALRESGPDCARLRALLNGPVDDDAEVREALTLLRASPGMARAKDVLAQYAAQARHELALLPDVPGRRALAALVDYTVSRHG
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