Gene Mb0689 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameend
Gene length759 bp
IdentifierMb0689
Location 771561 bp
Protein summary information
Molecular mass26845.2 Da
Isoelectric point5.3289
Protein length252 amino acids
Orthologues
M. tuberculosisRv0670
Cross-references
UniProtP63536
UniProtKB/TrEMBLX2BFK7, P63536
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE)
CommentsMb0689, end, len: 252 aa. Equivalent to Rv0670,len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 252 aa overlap). Probable end (alternate gene name: nfo), endonuclease IV (apurinase) (EC 3.1.21.2), equivalent to END_MYCLE|P30770|NFO|ML1889 probable endonuclease IV (apurinase) from Mycobacterium leprae (252 aa), FASTA scores: opt: 1463, E(): 0, (85.6% identity in 250 aa overlap). Also similar to others e.g. Q9S2N2|END4_STRCO|NFO|SC6E10.05 PROBABLE ENDONUCLEASE IV from Streptomyces coelicolor (294 aa); etc. Contains PS00729 AP endonucleases family 2 signatures 1 and 2 (PS00729, and PS00730). BELONGS TO THE AP ENDONUCLEASES FAMILY 2. COFACTOR: BINDS 3 ZINC IONS.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS771561772319+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0689|end
MLIGSHVSPTDPLAAAEAEGADVVQIFLGNPQSWKAPKPRDDAAALKAATLPIYVHAPYLINLASANNRVRIPSRKILQETCAAAADIGAAAVIVHGGHVADDNDIDKGFQRWRKALDRLETEVPVYLENTAGGDHAMARRFDTIARLWDVIGDTGIGFCLDTCHTWAAGEALTDAVDRIKAITGRIDLVHCNDSRDEAGSGRDRHANLGSGQIDPDLLVAAVKAAGAPVICETADQGRKDDIAFLRERTGS
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