Gene Mb0749c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameserA2
Gene length981 bp
IdentifierMb0749c
Location 822318 bp
Protein summary information
Molecular mass34420.2 Da
Isoelectric point5.987
Protein length326 amino acids
Orthologs
M. tuberculosis H37RvRv0728c
M. tuberculosis MTBC0mtbc0_000770
Cross-references
UniProtA0A1R3XW91
InterProIPR006139, IPR006140, IPR006236, IPR016040
UniProtKB/TrEMBLQ7U1E4
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA2 (PHOSPHOGLYCERATE DEHYDROGENASE) (PGDH)
CommentsMb0749c, serA2, len: 326 aa. Equivalent to Rv0728c,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 326 aa overlap). Possible serA2,D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95), similar to others e.g. AF0278|AF027868_5|YoaD D-3-phosphoglycerate dehydrogenase from Bacillus subtilis (344 aa), FASTA scores: opt: 594, E(): 3.1e-31, (35.9% identity in 309 aa overlap); etc. Also similar to Rv2996c|MTV012.10|SERA1 D-3-phosphoglycerate dehydrogenase from Mycobacterium tuberculosis (528 aa).
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS822318823298-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0749c|serA2
MTPRPRALVTAPLRGPGFAQLRRLADVVYDPWIDQRPLRIYSAEQLADRITAVAADVLVVESDSVGGPVFERGLRVVAATRGDPSNVDIPGATAAGIPVLHTPARNADAVAEMTVALLLAVARHLIPADADVRSGNIFRDGTIPYQRFRGAEIAGLTAGLVGLGAVGRAVRWRLSGLGLRVIAHDPYRDDAGHSLDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFLNTARSQLHDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIGGATWNTEARQARMVADDLGALLSGNRPAHVVNPEVLGS
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